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ASH Clinical Practice Guidelines

ASH Guidelines are developed by leading clinical, methodological, and patient experts through a rigorous process to review evidence and write actionable recommendations. Our state-of-the-art methodology ensures that they meet the highest standards for trustworthiness and transparency. Guideline panels are explicit about how recommendations were determined and open about the quality of evidence that factored into the final decision-making process.

Browse the existing guidelines below, and learn about guidelines currently in development, including those open for public comment. ASH also endorses other clinical guidelines of relevance to practicing hematologists.

Venous Thromboembolism

Ten ASH Clinical Practice Guidelines on Venous Thromboembolism covering prophylaxis for medical patients, diagnosis, anticoagulation therapy, heparin-induced thrombocytopenia, pregnancy, pediatrics, treatment, cancer, thrombophilia, prophylaxis in surgical patients, and anticoagulation in COVID-19 patients.

Sickle Cell Disease

Five ASH Sickle Cell Disease Guidelines covering cardiopulmonary and kidney disease, cerebrovascular disease, transfusion, transplantation, and pain management. 

Immune Thrombocytopenia

An update to the 2011 ASH Clinical Practice Guidelines for Immune Thrombocytopenia covering management of both adult and pediatric immune thrombocytopenia.

Acute Myeloid Leukemia

The ASH Clinical Practice Guidelines for Acute Myeloid Leukemia covers the treatment of acute myeloid leukemia in older adults.

Management of Cancer-Associated Anemia

A 2019 collaboration with the American Society of Clinical Oncology (ASCO) to address the management of cancer-related anemia.

Von Willebrand Disease

Two ASH Clinical Practice Guidelines on the diagnosis and management of VWD, in collaboration with the International Society on Thrombosis and Haemostasis (ISTH), National Hemophilia Foundation (NHF), and World Federation of Hemophilia (WFH).

Initial Workup of Acute Leukemia

Published in partnership with the College of American Pathologists, this guideline addresses the initial work-up of acute leukemia.


If you have questions or need assistance with any aspect of the guideline topic proposal form, please email guidelines@hematology.org.

Topic Proposal

Interested in submitting a guideline topic? Want to contribute to guideline development?

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Public Comment

All are welcome to comment on draft recommendations, including physicians, patients, caregivers, and members of the public.

Review Draft Guidelines

user guide to Guidelines 

Learn how patients, clinicians, policymakers, researchers, and others may interpret and apply guideline information.

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