ASH ISTH NHF WFH Clinical Practice Guidelines on von Willebrand Disease

The American Society of Hematology (ASH), in collaboration with the International Society on Thrombosis and Haemostasis (ISTH), National Hemophilia Foundation (NHF), and World Federation of Hemophilia (WFH), has developed clinical practice guidelines on the diagnosis and management of VWD.

• ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease
• ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease

Learn more about the development process behind the ASH ISTH NHF WFH VWD guidelines.

View the international survey which highlighted areas of importance to a diverse representation of stakeholders in the diagnosis and management of VWD, providing a framework for future guideline development and implementation.

• An international survey to inform priorities for new guidelines on von Willebrand disease

VWD Guidelines: What You Should Know

These one-page snapshots provides a high-level summary of the ASH ISTH NHF WFH VWD guidelines. A snapshot of the full VWD guidelines is also available for download.

Diagnosis of von Willebrand disease

Download the PDF| Arabic | Chinese | French | Russian | Spanish
Download the Full Translated Guideline | French | Spanish
Download the Executive Summary | Arabic | Chinese | French | Russian | Spanish

 Management of von Willebrand disease

Download the PDF| Arabic | Chinese | French | Russian | Spanish
Download the Full Translated Guideline | French | Spanish 
Download the Executive Summary | Arabic | Chinese | French | Russian | Spanish

Guideline Implementation Tools and Resources

ASH guidelines are reviewed annually by expert work groups convened by ASH. Resources derived from guidelines that require updating are removed from the ASH website.

ASH Clinical Practice Guidelines App

The ASH Clinical Practice Guidelines App provides easy access to every recommendation from all guidelines published by ASH, including rationale for each recommendation, benefits and harms associated with each recommended course of action, and links to the complete evidence-to-decision tables used to develop the recommendations. This app is also available via web interface.

Download for iOS    Download for Android

Webinar

This webinar highlights recommendations along with underlying evidence and rationale for the recommendations for the ASH ISTH NHF WFH guidelines on the diagnosis and management of von Willebrand disease.

Watch Webinar

Teaching Slides

Help your colleagues diagnose, manage, and treat VWD with the following teaching slides designed for easy dissemination:

• Diagnosis and Management of VWD
  Powerpoint | PDF

Additional resources

The following resources, developed externally and based on the ASH ISTH NHF WFH VWD guidelines, are provided for reference. Please note that the American Society of Hematology does not endorse, nor is it responsible for, the content of these resources

• ISTH resources
• NHF resources
  • Patient Summary of the Guidelines – Management of VWD
  • Patient Summary of the Guidelines – Diagnosis of VWD
• WFH resources
  • WFH Virtual Summit 2020: Patient Focus – ASH ISTH NHF WFH Guidelines on the Diagnosis and Management of VWD
• The Haemophilia Journal has published the commentary, Diagnosis and management of von Willebrand disease: A community‐wide effort to deliver evidence‐based clinical practice guidelines by Barb Konkle on behalf of the World Federation of Hemophilia and Steve Pipe on behalf of the National Hemophilia Foundation
• The Center for Disease Control's Division of Blood Disorders (DBD) is proud to offer its Public Health Webinar Series on Blood Disorders entitled Joint Guidelines on the Diagnosis and Management of von Willebrand Disease. The purpose of this series is to provide evidence-based information on new research, interventions, emerging issues of interest in blood disorders, as well as innovative approaches in collaborations and partnerships. Watch the webinar here.