ASH ISTH NHF WFH Clinical Practice Guidelines on von Willebrand Disease
The American Society of Hematology (ASH), in collaboration with the International Society on Thrombosis and Haemostasis (ISTH), National Hemophilia Foundation (NHF), and World Federation of Hemophilia (WFH), has developed clinical practice guidelines on the diagnosis and management of VWD.
- ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease
- ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease
Learn more about the development process behind the ASH ISTH NHF WFH VWD guidelines.
View the international survey which highlighted areas of importance to a diverse representation of stakeholders in the diagnosis and management of VWD, providing a framework for future guideline development and implementation.
VWD Guidelines: What You Should Know
These one-page snapshots provides a high-level summary of the ASH ISTH NHF WFH VWD guidelines. A snapshot of the full VWD guidelines is also available for download.
Diagnosis of von Willebrand disease

Download the PDF
Download the Spanish translation
Download the French translation
Management of von Willebrand disease

Download the PDF
Download the Spanish translation
Download the French translation
Guideline Implementation Tools and Resources
Webinar
Monday, January 25, 2021, at 2:00 p.m. Eastern time
This 90-minute webinar will highlight the guideline recommendations along with the underlying evidence and rationale for the recommendations.
Register for the webinar here.
World Federation of Hemophilia Global Summit
Watch the WFH Global Summit on Women & Girls with Inherited Bleeding Disorders here.
Additional resources
The following resources, developed externally and based on the ASH ISTH NHF WFH VWD guidelines, are provided for reference. Please note that the American Society of Hematology does not endorse, nor is it responsible for, the content of these resources
ASH Clinical Practice Guidelines App
The ASH Clinical Practice Guidelines App provides easy access to every recommendation from all guidelines published by ASH, including rationale for each recommendation, benefits and harms associated with each recommended course of action, and links to the complete evidence-to-decision tables used to develop the recommendations. This app is also available via web interface.