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ASH Clinical Practice Guidelines on Sickle Cell Disease

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of experts discussing the new guidelines.

In 2016, ASH initiated an effort to develop clinical practice guidelines on Sickle Cell Disease (SCD). ASH appointed 61 clinical experts, five methodologists and 10 patient representatives to review evidence and form recommendations on SCD. The recommendations address treatment of both adult and pediatric SCD. The systematic review of evidence was led by the Mayo Clinic Evidence-Based Practice Center.

Learn more about the development process behind the SCD guidelines.

Access the full guidelines on the Blood Advances website.

American Society of Hematology 2019 Guidelines for Sickle Cell Disease: Cardiopulmonary and Kidney Disease

Available Guidelines

Coming soon:

  • Management of Acute and Chronic Pain
  • Transplantation

Understanding SCD

Download the PDF.

SCD Guideline Methodology Infographic

Download the PDF

Guideline Implementation Tools and Resources


ASH Clinical Practice Guidelines App

The ASH Clinical Practice Guidelines App provides easy access to every recommendation from all guidelines published by ASH, including rationale for each recommendation, benefits and harms associated with each recommended course of action, and links to the complete evidence-to-decision tables used to develop the recommendations. This app is also available via web interface.

Download for iOS    Download for Android

ASH Pocket Guides App

The ASH Pocket Guides App includes all of ASH’s pocket guides. This app is also available via web interface.

Download for iOS    Download for Android

Teaching Slides

Help your colleagues diagnose, manage, and treat SCD with teaching slides designed for easy dissemination. Slide sets are available for the following ASH guidelines:

Pocket Guides

Free printed versions of pocket guides are available for order on the ASH website, and at ASH meetings throughout the year. The following pocket guide is based on the 2019 ASH Clinical Practice Guidelines for SCD:

  • Cardiopulmonary and Kidney Disease in Sickle Cell Disease: Screening and Management
    ASH Store


Listen to the podcasts below to learn more about ASH's clinical guidelines.