ASH Sickle Cell Guidelines: Stem Cell Transplantation

Over recent years, growing experience with allogeneic hematopoietic stem cell transplantation (HSCT) has underscored its role as the only currently available potentially curative therapy for sickle cell disease (SCD), while also highlighting important risks that must be carefully weighed against standard disease-modifying and supportive treatments. The ASH Clinical Practice Guidelines on SCD: Stem Cell Transplantation provide evidence-based recommendations to help clinicians and individuals with SCD determine who should be considered for HSCT, when in the disease course to pursue transplant, and how donor options influence decision-making. Developed for hematologists, internists, general practitioners, pediatricians, and other members of the care team, these guidelines aim to support shared, informed discussions with patients and families about indications, benefits, and risks of HSCT, and to identify priority areas where additional research is needed to guide future curative strategies, including gene-based therapies.

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Guideline Implementation Tools and Resources

ASH Clinical Practice Guidelines App

The ASH Clinical Practice Guidelines App provides access to the recommendations with links to the complete evidence-to-decision tables used to develop them.

Decision Aid

In partnership with the Mayo Clinic Shared Decision Making National Resource Center, ASH has developed a shared decision-making tool to support clinicians and patients with SCD in considering transplantation as a treatment option. 