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ASH Annual Meeting and Exposition

Special Scientific Symposia

The Special Scientific Symposia feature presentations that cover the latest scientific developments that cut across many sub-disciplines of hematology and appeal to a wide audience.

Unless otherwise noted, all sessions will take place in person and stream simultaneously on the virtual platform. Session recordings will be available on demand on the virtual platform.

Cellular Heterogeneity and Relationship to Clinical Outcomes

Cellular therapies are quite heterogeneous by nature, but regulatory and industry groups have focused on defining particular products with "critical product attributes" while minimizing heterogeneity. This session will highlight the potential benefits of cellular heterogeneity, in both immune effector cells and within post-transplant cell populations.

Chair:

Craig Byersdorfer, MD
University of Pittsburgh
Pittsburgh, PA

Speakers:

Zinaida Good, PhD
Stanford University School of Medicine
Stanford, CA
Heterogeneity of CD19 CAR T Cells

Julia Carnevale, MD
University of California San Francisco
San Francisco, CA
Purposeful Heterogeneity of CAR T Cells

Megan Levings, PhD
University of British Columbia, Canada
Vancouver, BC, CAN
Heterogeneity of Cells in Transplantation

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Interphase of Complement and Coagulation

The complement system and coagulation pathways are the main pillars of immunity and hemostasis respectively that undergo significant activation with injury. While appearing distinct, it is recognized that significant crosstalk exists between the two systems and recently established molecular mechanisms provide insights into a wide variety of disorders. This session will focus on new molecular links identified in complement activation in specific and highly relevant clinical disorders.

Chair:

David Kavanagh, PhD
New Castle University
Newcastle Upon Tyne, United Kingdom

Speakers:

David Kavanagh, PhD
New Castle University
Newcastle Upon Tyne, United Kingdom
Complement and the Prothrombotic State

Efthymia Vlachaki, MBBS
Hippokrateon Hospital
Thessaloniki, GRC
Complement Activation and Preclampsia

Lubka Roumenina, PhD
INSERM, Centre De Recherche Des Cordeliers
Paris, FRA
Sickle Cell Disease and Complement Activation

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Interrogating the Impact of the Intestinal Microbiome on Transplant and Cellular Therapies

Fundamental advances have been achieved in the treatment of patients with hematologic malignancies through transplant and cellular therapy (TCT), including hematopoietic cell transplant and chimeric antigen receptor (CAR) T cell therapy. However, the therapies have limitations, such as relapses and toxicity. TCT outcomes have been associated with the intestinal microbiome. This session will focus on the intestinal microbiome in relation to TCT, from correlative research to interventional studies.

Chair:

Melody Smith, MD,MS
Stanford University
Stanford, CA

Speakers:

Florent Malard, MD, PhD
Hôpital Saint-Antoine
Paris, France
Fecal Microbiota Transplant As a Strategy to Mitigate Infection and Gvhd Following TCT

Lawrence David, PhD
The David Lab at Duke University
Durham, NC
Deciphering Nutritional Intake from Metagenomic Data Using Computational Tools

Tessa Andermann, MD,MPH
University of North Carolina, Chapel Hill
Chapel Hill, NC
Impact of Antibiotic Exposure on Outcomes Following TCT

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Newly Discovered Functions of Megakaryocytes and Platelets

This session will reveal new mechanisms of diseases related to platelet formation and function. Specifically, it will address glycosylation in megakaryocytes (Mks)/platelet functions and diseases; and highlight new insights in thromboinflammation, functions, and diseases of Mks and platelets.

Chair:

Alessandra Balduini, MD
Tufts University
Medford, MA

Speakers:

Karin M. Hoffmeister, MD
Versiti Blood Research Institute, Milwaukee, WI
Milwaukee, WI
Glycans and New Pathogenic Mechanisms of ITP

Tobias Petzold, MD, MSc
Charité – Universitätsmedizin Berlin
Berlin, Germany
Regulation of Platelet Function During Immobilty

Anna S. Nam, MD
Weill Cornell University
NEW YORK, NY
Platelet ER Stress in Thrombosis

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Placing the Brakes on Accelerated Aging

Hematologic disorders disproportionately affect older adults; despite this, our understanding of the implications of age on the pathogenesis and treatment of these diseases remains limited. The geroscience field is actively investigating geriomics to aid in distinguishing biological and chronological aging. This session will highlight biological aging assessments for hematologic disease which will be crucial for the identification of targets and development of therapies for this specific population.

Chair:

Ashley E Rosko, MD
The Ohio State University
Columbus, OH

Speakers:

Els Mansell, PhD
Erasmus Medical Center
Rotterdam, Netherlands
Ageing of Hematopoietic Stem Cells and Their Niche

Christin E. Burd, PhD
The Ohio State University
Columbus, OH
Geroscience and Geri-Omics in Hematologic Malignancies

Marcel R.M. van den Brink
Sloan Kettering Institute
New York, NY
Targeting Rejuvenation Therapies to Decelerate Aging

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Special Symposium on the Basic Science in Hemostasis and Thrombosis

This session will highlight emerging topics and the latest discoveries in regulating inflammation at the cross-section of hemostasis, platelets, and vascular biology.

Co-Chairs:

Laurent O. Mosnier, PhD
The Scripps Research Inst.
La Jolla, CA

Hartmut Weiler, PhD
Versiti Blood Research Institute
Milwaukee, WI

Lijun Xia, MD, PhD
Oklahoma Medical Research Foundation
Oklahoma City, OK

Speakers:

Yesim Dargaud, MD, PhD
Université Lyon
Lyon, France
Efficacy of Platelet-Inspired Hemostatic Nanoparticles on Bleeding in Von Willebrand Disease Murine Model

Jieqing Zhu, PhD
Versiti Blood Research Institute
Milwaukee, WI
Platelet Integrin Structure, Function and Role in Disease

Yu Hou
Qilu Hospital, Cheeloo College of Medicine, Shandong University
Jinan, CHN
Platelet TGFb1 in the Pathogenesis of Immune Thrombocytopenia Purpura