Hematopoiesis
For Trainees, By Trainees
Thank you for visiting the Hematopoiesis website! Hematopoiesis is a publication by trainees, for trainees. This publication was created as a virtual space for learning and collaboration amongst hematology-inclined trainees and researchers at all levels. Over the years, we have received submissions from trainees, spanning from case reports to opinion pieces. We constantly strive to represent all trainees and diverse topics relevant to trainees. We welcome you to submit a contribution and join our growing author list!
Contribute to Hematopoiesis: Submit your case study or research article to us!
Featured Content
Immune Effector Cell-Associated HLH-Like Syndrome as a Post CAR T-Cell Therapy Complication of Lymphoid Malignancies
Mulham Ombada, MD
Michael Sandhu, MD
Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the treatment landscape of lymphoid malignancies. However, the remarkable efficacy of CAR-T therapy is hindered by its toxicities, including an emergent one known as immune effector cell (IEC)-associated hemophagocytic lymphohistiocytosis (HLH)-like syndrome (IEC-HS), a severe and potentially life-threatening complication. This article reviews the clinical manifestations, pathophysiology, and management of IEC-HS following CAR-T therapy in B-cell malignancies.
Amplify Your ASH Annual Meeting Experience: Tips for Trainees
Kaitlyn Dykes, MD Maya Abdallah, MD
Congratulations on attending the 66th ASH Annual Meeting and Exposition! Whether you’re a seasoned conference-goer or a first-time attendee, this guide has everything you need to amplify your experience.
Hearts of Hematology
Anika Patel, BS
It is with great pleasure that the ASH Trainee Council introduces Hearts of Hematology (HoH), an anthology of hematology-related stories of love, loss, and hope to be posted on ASH’s social media channels, specifically Instagram and LinkedIn. In creating a space to reflect together on shared experiences, we hope to showcase all the unique aspects of a career in this field, while revealing where the hearts of hematologists and oncologists truly lie.
53-Year-Old Woman With Abdominal Pain, Anemia, and Indirect Hyperbilirubinemia
Alyssa Jones, MD Nneka Nwachukwu, MD
Hugo Lara-Martinez, MD
A 53-year-old woman from Vietnam with a reported past surgical history of cholecystectomy and splenectomy presented to the emergency room with a three-day history of right upper quadrant abdominal pain and fatigue.
A Practical Approach to Childbearing in Fellowship Training
Jennifer H. Cooperrider, MD Kaitlyn C. Dykes, MD
Lacey Williams, MD
Case: You are a G0P0 fellow in hematology-oncology and find out that you are pregnant. You have started to experience some pregnancy-associated symptoms and are feeling somewhat overwhelmed by the realities of pregnancy. What can you do to integrate your pregnancy and future child into your medical training?
A Case of Hematological Malignancy in Pregnancy: Therapeutic Complexities
Hina Khan, MD
Rabab Jafry
A 29-year-old woman (G3P2) at 6 weeks of gestation presented to the emergency department for vaginal bleeding over the preceding few days.
Management of Crystal Cryoglobulinemia in a Patient With Chronic Lymphocytic Leukemia
Ashley Dunton, MD
Shivi Jain, MD
A 64-year-old man with a history of heart failure with preserved ejection fraction and hypertension presented with progressive dyspnea.
Ureaplasma-induced Hyperammonemic Encephalopathy: An Acute Complication Post Haploidentical Allogenic Stem Cell Transplant
Rohail Badami
Michael Radford, MD
A 32-year-old woman with acute lymphoblastic lymphoma received a haploidentical allogeneic stem cell transplant (HSCT)
IgA Deficiency, Immune Globulin Treatment, and Pregnancy
David Daniel, MD
A Case of Melena in a Patient with Esophageal Adenocarcinoma: When Cytopenia Persists Despite Supportive Transfusions
Navya George, MD Maya Abdallah, MD
Rahul Ganatra, MD, MPH
A 73-year-old man with a medical history of stage III esophageal adenocarcinoma treated with neoadjuvant chemoradiotherapy, pulmonary embolism (PE) treated with a direct oral anticoagulant, and recent hospitalization for babesiosis presented with melena, persistent daily fevers, and hematuria.
Across the World of Medicine: Perspectives of an International Medical Graduate
Phyu Thin Naing, MBBS
Growing up in Myanmar, raised by physician parents, I saw health care as not just a profession but a way of life. I became acquainted with the realities of illness and mortality at the age of 5 when I witnessed my grandmother's battle with stage 4 lung cancer. Her oncologist's unwavering support left an impression on me that planted the seed of interest in medicine.
Cardiotoxicity in Malignant Hematology: A Focus on CAR T-cell Therapy
Christina Snider, MD
Tanim Jain, MD
Treatment-related cardiotoxicity has been increasingly recognized as a challenge in the clinical management of cancer. Frequently used cancer drugs associated with a high risk of cardiotoxicity include anthracyclines, BCR-ABL kinase inhibitors, proteasome inhibitors, and Bruton tyrosine kinase inhibitors (BTKIs). Less is known about the potential acute and long-term cardiotoxic effects of chimeric antigen receptor T-cell (CAR-T) therapy, which has emerged as an efficacious treatment for hematologic malignancies.
Jak in the Brain: An Incidental Hematologic Malignancy Diagnosed From a Metastatic Lung Adenocarcinoma by Next Generation Sequencing
Eric Vick, MD, PhD
John Steffes, MD
Dr. Eric Vick (@Nodlike) and Dr. John Steffes describe the case of a man with long-standing mild leukocytosis found to have a brain mass, which was biopsied confirming metastatic recurrence of lung adenocarcinoma. Notably, molecular testing to the cerebral biopsy sample demonstrated a JAK2 mutation. The mutation was also found in a peripheral blood sample prompting further workup that led to the diagnosis of myelofibrosis.
#SHEmatologists: Recap of Women in Hematology Working Group at #ASH22 and What’s
Next
Rebecca Zon, MD
Xu Han, MD, PhD
Dr. Becky Zon and Dr. Xu Han highlights the ASH Women in Hematology Working Group activities at the ASH Annual Meeting and what is next on the horizon.
Superior Vena Cava Syndrome
Ricardo Ortiz, MD
A Thick Problem
Valentina Baez Sosa, MD
Kamille West-Mitchell, MD
James Kochenderfer, MD
Dr. Valentina Baez Sosa (@ValenBaezS), Dr. Kamille West-Mitchell (@Kwestmitchell), and Dr. James Kochenderfer describe the case of a 56-year-old man diagnosed with immunoglobulin A (IgA) kappa multiple myeloma who was treated with multiple chemotherapeutic regimens with a response and subsequent relapse.
Cardiac Considerations With Carfilzomib in a Patient Diagnosed With Multiple Myeloma
Aula Ramo, MD
Cortney McKay, MD
Vrushali Dabak, MD
Superior Vena Cava Syndrome
Ricardo Ortiz, MD
Adriana Malone, MD
Emergency Department Management of Sickle Cell Disease: A Point-of-Care Tool
Logan Ramsey, MD
Caroline Freiermuth, MD, MS, FACEP
Mentoring Matters: Perspectives From Basic Science Hematology Investigators
(Part 3)
Xu Han, MD, PhD
Moua Yang, MD, PhD
Dr. Xu Han (@PARty4Ever_) and Dr. Moua Yang (@MouaYang21) describe how a healthy mentor-mentee relationship is critical for academic and career success.
Mentoring Matters: Perspectives From Basic Science Hematology Investigators
(Part 2)
Xu Han, MD, PhD
Moua Yang, MD, PhD
Dr. Xu Han (@PARty4Ever_) and Dr. Moua Yang (@MouaYang21) describe how a healthy mentor-mentee relationship is critical for academic and career success.
Mentoring Matters: Perspectives From Basic Science Hematology Investigators
(Part 1)
Xu Han, MD, PhD
Moua Yang, MD, PhD
Dr. Xu Han (@PARty4Ever_) and Dr. Moua Yang (@MouaYang21) describe how a healthy mentor-mentee relationship is critical for academic and career success.
How Research as a Medical Student Shaped My Career Trajectory
Macy L. Early, MS4
Lydia H. Pecker, MD
Macy Early, MS4 (@macy_early), with her mentor Dr. Lydia Pecker (@LydiaPecker), reflects on the ways engaging in research shaped her career trajectory and aspirations throughout medical school, as she discovered a love for sickle cell disease and healthcare delivery sciences through research in reproductive health.
I’ve registered for ASH. Now what?
Ajay Major, MD, MBA
Rebecca Zon, MD
Explore the Latest Case Studies and Articles From Hematopoiesis
53-Year-Old Woman With Abdominal Pain, Anemia, and Indirect Hyperbilirubinemia
A 53-year-old woman from Vietnam with a reported past surgical history of cholecystectomy and splenectomy presented to the emergency room with a three-day history of right upper quadrant abdominal pain and fatigue. While her physical exam was notable...
Read moreAcross the World of Medicine: Perspectives of an International Medical Graduate
Growing up in Myanmar, raised by physician parents, I saw health care as not just a profession but a way of life. I became acquainted with the realities of illness and mortality at the age of 5 when I witnessed my grandmother's battle with stage 4 lu...
Read moreIgA Deficiency, Immune Globulin Treatment, and Pregnancy
David Daniel, MD @DavidDanielMD Clinical Fellow Department of Transfusion Medicine National Institutes of Health Bethesda, MD
Read moreA THICK PROBLEM
Dr. Valentina Baez Sosa (@ValenBaezS), Dr. Kamille West-Mitchell (@Kwestmitchell), and Dr. James Kochenderfer describe the case of a 56-year-old man diagnosed with immunoglobulin A (IgA) kappa multiple myeloma who was treated with multiple chemotherapeutic regimens with a response and subsequent relapse.
Read moreJak in the Brain: An Incidental Hematologic Malignancy Diagnosed From a Metastatic Lung Adenocarcinoma by Next Generation Sequencing
Dr. Eric Vick (@Nodlike) and Dr. John Steffes describe the case of a man with long-standing mild leukocytosis found to have a brain mass, which was biopsied confirming metastatic recurrence of lung adenocarcinoma. Notably, molecular testing to the cerebral biopsy sample demonstrated a JAK2 mutation. The mutation was also found in a peripheral blood sample prompting further workup that led to the diagnosis of myelofibrosis.
Read more#SHEmatologists: Recap of Women in Hematology Working Group at #ASH22 and What’s Next
Dr. Becky Zon and Dr. Xu Han highlights the ASH Women in Hematology Working Group activities at the ASH Annual Meeting and what is next on the horizon.
Read moreI’ve Registered for ASH. Now What?
Although the 64th ASH Annual Meeting is listed as taking place from December 10-13 in New Orleans, you will not want to miss our huge trainee-dedicated event, ASH-a-Palooza, occurring on December 9 at the extravagant Mardi Gras World! ASH-a-Palooza i...
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