American Society of Hematology

ASH Clinical Practice Guidelines on Venous Thromboembolism

VTE_Video_ThumbnailClick image for video of experts discussing the new guidelines.

In 2014, in response to long-standing member interest, ASH initiated an effort to develop evidence-based clinical practice guidelines for hematology that meet the highest standards of development, rigor and trustworthiness. Development of these guidelines, including systematic evidence review, was supported by the McMaster University GRADE Centre, a world leader in guideline development. With their partnership, ASH brought together ten panels of more than 100 thrombosis experts to review evidence and formulate more than 200 recommendations on venous thromboembolism (VTE).

VTE Guideline Development

VTE Guidelines Development Inforgraphic Feature

Download the PDF.

Understanding Blood Clots

Understanding Bloodclots - Feature

Download the PDF.

VTE Clinical Practice Guidelines Snapshot

VTE Clinical Practice Guidelines Snapshot Feature

Download the PDF.

Signs of VTE

Signs of VTE Infographic Feature

Download the PDF.

The ASH VTE guidelines have been endorsed by the following organizations:

  • American Association of Hip and Knee Surgeons (AAHKS)
  • Anticoagulation Forum (AC Forum)
  • Eastern Association for the Surgery of Trauma (EAST)
  • Foundation for Women & Girls with Blood Disorders (FWGBD)
  • International Society on Thrombosis and Haemostasis (ISTH)

Learn more about the development process behind the VTE guidelines.


back to top

Guideline Implementation Tools and Resources

ASH Clinical Practice Guidelines App

The ASH Clinical Practice Guidelines App provides easy access to every recommendation from all guidelines published by ASH, including rationale for each recommendation, benefits and harms associated with each recommended course of action, and links to the complete evidence-to-decision tables used to develop the recommendations. This app is also available via web interface.

ASH Pocket Guides App

The ASH Pocket Guides App includes all of ASH’s pocket guides, including the 2018 pocket guide on the Diagnosis and Management of Heparin-Induced Thrombocytopenia (HIT). In addition to the pocket guides, the app contains tools and calculators to aid in clinical decision making, including a 4Ts calculator (updated based on the 2018 guidelines). This app is also available via web interface.

ASH Pocket Guides

Printed versions of pocket guides are available for order on the ASH website, and at ASH meetings throughout the year. The following pocket guide is based on the 2018 ASH Clinical Practice Guidelines for Management of VTE:

  • Diagnosis and Management of Heparin-Induced Thrombocytopenia (HIT)
    ASH Store | PDF

Teaching Slide Sets

Help your colleagues diagnose, manage, and treat VTE with teaching slides designed for easy dissemination. Slide sets are available for the following ASH guidelines:

Patient Versions of the Selected Recommendations

ASH and McMaster University are developing patient versions of selected recommendations that can be shared with patients, care givers, and other non-clinical audiences.


Listen to the podcasts below to learn more about ASH's VTE guidelines.


VTE Guidelines for Latin America

In partnership with the McMaster University GRADE Centre and Latin American hematology societies, ASH is piloting a project to develop adapted VTE guidelines for use in Latin America. Hematologists representing 12 different societies from the region have been appointed to serve on this panel. The panel will select questions from the original ASH VTE guidelines that are clinically significant in Latin America and will reassess the evidence to form recommendations. Publication of these guidelines is anticipated in 2019.

back to top