Scientific Spotlight Sessions

Human Pluripotent Stem Cell-Derived Hematopoiesis: From Development to Stem Cell Therapies

Please view the pre-recorded presentations prior to attending the corresponding Live Q&A session. Access to the on-demand content will be available starting on December 8 and will continue through the duration of your meeting subscription. CME is available for participation in the corresponding Live Q&A.

Of Lineage and Legacy: Applications of Lineage Tracing in Hematology

Please view the pre-recorded presentations prior to attending the corresponding Live Q&A session. Access to the on-demand content will be available starting on December 8 and will continue through the duration of your meeting subscription. CME is available for participation in the corresponding Live Q&A.

The cellular hierarchies and relationships that occur in normal physiology and pathologic conditions have been of great interest. Important insights into these processes have recently arisen from genetic labeling studies in model organisms. However, the ability to discern such relationships in unmodified human tissues has been challenging. In this spotlight session, two complementary approaches that enable such hierarchies to be deciphered using nuclear and mitochondrial somatic mutations will be discussed. Dr. Vijay Sankaran will discuss the value of mitochondrial DNA lineage tracing approaches that his group has developed, discuss recent technologic advances to enable multi-modal insights along with lineage information, and discuss applications to non-malignant and malignant hematology. Dr. Jyoti Nangalia will discuss how nuclear somatic mutations can enable the reconstruction of cellular hierarchies, advances in the approaches that can be used for such phylogenetic inferences, and applications in hematology that her group has studied.