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Programs

Scientific Program

Aberrant Transcriptional Regulation in Development and Malignancies

Scientific Committee on Epigenetics and Genomics

Chair:

Ruud Delwel , MD, PhD
Erasmus MC Cancer Institute
Rotterdam,  Rotterdam, Netherlands

Speakers:

Marc R. Mansour , MBChB, PhD, MRCP, FRCPath
University College London Cancer Center
London,  WAL, United Kingdom
Non-coding Mutations in Disease: Enhancer and Promoter Mutations in the Pathogenesis of T-cell Acute Lymphoblastic Leukemia

Kathrin M. Bernt , MD
Children's Hospital of Philadelphia
Philadelphia,  PA
Enhancer Hijacker in Leukemia: MN1 Translocations in Acute Myeloid Leukemia

Jolanta Grembecka
University of Michigan
Ann Arbor,  MI
IDRs in Transcription Control in Development and Disease

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AI, Data Science, Computer Vision and the Hematology Laboratory of the Future

Scientific Committee on Hematopathology & Clinical Laboratory Hematology

Chair:

Scott J. Rodig , MD, PhD
Brigham and Women's Hospital
Boston,  MA

Speakers:

Yinyin Yuan , PhD
The Institute for Cancer Research
London,  WAL, United Kingdom
Computational/ Artificial Intelligence Methods for Evaluating Tissue Samples

Metin Gurcan , PhD
Wake Forest School of Medicine
Winston Salem,  NC
Application of Artificial Intelligence/ Computer Vision in Tissue Biopsy Evaluation

David L. Jaye , MD
Emory University
Dunwoody,  GA
Application of Artificial Intelligence/ Computer Vision in Bone Marrow and Peripheral Blood Evaluations

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Blood Therapeutics in Pandemics

Scientific Committee on Transfusion Medicine

Chair:

Simone A. Glynn , MD,MPH
National Heart, Lung, and Blood Institute
Bethesda,  MD

Speakers:

Ruchika Goel , MD, MPH
Southern Illinois University School of Medicine
Springfield,  IL
Convalescent Plasma and Emerging Infections: Potential Mechanisms of Action

Pampee Young , MD
American Red Cross
Washington,  DC
Situation Critical! Securing and Managing the Blood Supply During the COVID-19 Pandemic Response

Jacques Le Pendu , PhD
University; De Nantes
Nantes,  NULL, France
ABO Matters: How Carbohydrate Antigens Influence Infectious Pathophysiology and Related Hematologic Outcomes

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Cellular Memory and Innate Immune Pathways During Myeloid Cell Development and Infection

Scientific Committee on Myeloid Biology

Chair:

Marie-Dominique Filippi , PhD
Cincinnati Children's Hospital Research Foundation
Cincinnati,  OH

Speakers:

Mihai Netea , MD, PhD
Radboud University Nijmegen Medical Centre
Nijmegen,  NULL, Netherlands
Metabolic Control of Trained Immunity for Monocyte Response to Infection

Sandrine Sarrazin , PhD
Inserm
Marseille,  France
Molecular Regulation of Cellular Memory and Trained Immunity

Eirini Trompouki , PhD
Max Planck Institute of Immunobiology and Epigenetics
Freiburg,  Germany
Role of Innate Immune Pathways in Myeloid Cell Development

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From Structure to Function: Next Generation Iron Therapeutics

Scientific Committee on Iron and Heme

Chair:

Sant-Rayn Pasricha , MD
Walter and Eliza Hall Institute of Medical Research
Fitzroy North,  VIC, Australia

Speakers:

Aashish Manglik , MD, PhD
University of California, San Francisco
San Francisco,  CA
Cryo-EM Structure of Ferroportin-Hepcidin Interactions

Yvette Y. Yien , PhD
University of Pittsburgh
Pittsburgh,  PA
Iron Transport Studies in Model Organisms

Dorine W. Swinkels , MD, PhD
Radboud University
Nijmegen,  NULL, Netherlands
Next Generation Drugs for Iron Metabolism

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Immune Evasion and Immunotherapy in Myeloid Malignancies

Scientific Committee on Myeloid Neoplasia

Chair:

Satu Mustjoki , MD,PhD
University of Helsinki
Helsinki,  Helsinki, Finland

Speakers:

Sergio Rutella , MD,PhD,FRCPath
Nottingham Trent University
Notingham,  ENG, United Kingdom
Overview of the Immune Dysregulation in Myeloid Malignancies

Johanna Olweus , MD, PhD
Oslo University Hospital
Oslo,  NULL, Norway
Novel Immunological Mechanisms Targeting Myeloid Malignancies (T Cell Based Therapies)

Saar Gill , MD, PhD
University of Pennsylvania School of Medicine
Philadelphia,  PA
Protecting Normal Hematopoiesis in Myeloid Malignancies Against Immunotherapies

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Immune Response to Old and New Enemies

Scientific Committee on Immunology and Host Defense

Chair:

Katharine C. Hsu , MD, PhD
Memorial Sloan Kettering Cancer Center
New York,  NY

Speakers:

Akiko Iwasaki , PhD
Yale University School of Medicine
New Haven,  CT
Immune responses to SARS-CoV-2

Alessandro Sette , Dr. Biol. Sci.
La Jolla Institute for Immunology
La Jolla,  CA
Selective and Cross-Reactive Sars-Cov-2 Epitopes

Marion Pepper , PhD
Fred Hutchinson Cancer Research Center
Seattle,  WA
Memory Response to Pathogens

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JOINT Session - Gene Editing 2.0: Advances in Gene Editing to Treat Genetic Blood Disorders

Scientific Committee on Blood Disorders in Childhood||Scientific Committee on Hematopoiesis

Co-Chairs:

Alan B. Cantor , MD, PhD
Harvard University
Boston,  MA

Simon Mendez-Ferrer , PhD
University of Cambridge
Cambridge,  Cambridge, United Kingdom

Speakers:

Paula Rio , PhD
CIEMAT-Hematopoietic Innovative Therapies
Madrid,  NULL, Spain
Gene Editing for Hematologic Disorders - an Expanding Toolbox

Punam Malik , MD
Cincinnati Children's Hospital Medical Center
Cincinnati,  OH
Applied Novel Gene Editing to Treat Beta-Hemoglobinopathies II

David Liu , PhD
Harvard University
Cambridge,  MA
Rescuing Genetic Diseases in Animals Through Ex Vivo and In Vivo Base Editing

Nicole M. Gaudelli , Ph.D.
Beam Therapeutics
Cambridge,  MA
Applied Base Editing to Treat Beta-Hemoglobinopathies

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Large Population Genomic Studies and Red Cell Disorders: A Revisionist View

Scientific Committee on Red Cell Biology

Chair:

Saghi Ghaffari , MD, PhD
Icahn School of Medicine at Mount Sinai
New York,  NY

Speakers:

Nicole Soranzo , PhD
Wellcome Sanger Institute
Cambridge,  ENG, United Kingdom
Polygenic Variation Impacting Presumed Monogenic Blood Disorders

Laura Raffield , PhD
University of North Carolina Chapel Hill
Chapel Hill,  NC
Genetic Modifiers of Sickle Cell Trait and Disease, Polygenic Trait Scores in Black Populations

Steven A. McCarroll , PhD
Harvard Medical School
Boston,  MA
Clonal Hematopoiesis and Inherited Variants

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Lymphoid Neoplasia: Genetics of Predisposition and Precursors

Scientific Committee on Lymphoid Neoplasia

Chair:

Susan L. Slager , PhD
Mayo Clinic
Rochester,  MN

Speakers:

James R. Cerhan , MD, PhD
Mayo Clinic
Rochester,  MN
Genetic Predisposition of Lymphoma

Geffen Kleinstern , PhD
University of Haifa
Haifa,  NULL, Israel
Monoclonal B-Cell Lymphocytosis: Genetic Predisposition and Progression to CLL

Sandrine Roulland , PhD
Inserm
Marseille,  NULL, France
Early Lesions of Follicular Lymphoma

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Molecular Basis of Disease Progression in Plasma Cell Precursor Diseases

Scientific Committee on Plasma Cell Neoplasia

Chair:

Shaji Kumar , MD
Mayo Clinic
Rochester,  MN

Speakers:

Giada Bianchi , MD
Brigham and Women's Hospital
Boston,  MA
Role of Tumor Microenvironment in Disease Progression from MGUS and SMM

Niccolo Bolli , MD
University of Milan
Milan,  NULL, Italy
Genetic Evolution across the Disease Spectrum from MGUS to MM

Sigurdur Yngvi Kristinsson , MD, PhD
University of Iceland
Reykjavik,  NULL, Iceland
Molecular Targets for Early Intervention

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Novel Findings in CAR-T Cell Therapies for Hematologic Malignancies

Scientific Committee on Transplantation Biology and Cellular Therapies

Chair:

Marcela V. Maus , MD
Massachusetts General Hospital, Harvard Medical School
Lexington,  MA

Speakers:

Marcela V. Maus , MD
Massachusetts General Hospital
Boston,  MA
Signaling in CAR-T cells

David Baker , PhD
University of Washington
Seattle,  WA
Combinatorial Signaling in CAR T Cells

Marco Ruella , MD
University of Pennsylvania
Philadelphia,  PA
Resistance Mechanisms to CAR-T Cells in ALL

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Platelets, Megakaryocytes and the Immune Continuum

Scientific Committee on Megakaryocytes and Platelets

Chair:

Elizabeth E. Gardiner , PhD
Australian National University
Canberra,  ACT, Australia

Speakers:

Milka Koupenova , PhD
University of Massachusetts Medical School
Worcester,  MA
Platelets and SARS-CoV-2: Implications to Immunity

Robert A. Campbell , PhD
University of Utah School of Medicine
Salt Lake City,  UT
Platelets in the War Against Viremia

Craig N. Morrell , PhD
University of Rochester
Rochester,  NY
Megakaryocytes and Immunity

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Regulators of Hematopoietic Stem Cell Development and Expansion: Bench to Bedside

Scientific Committee on Stem Cells and Regenerative Medicine

Chair:

Igor I Slukvin , MD
University of Wisconsin Madison
Madison,  WI

Speakers:

Hanna Mikkola
University of California, Los Angeles
Los Angeles,  CA
Developmental Regulators in Normal and Malignant Stem Cells

Satoshi Yamazaki
University of Tokyo
Tokyo,  TKY, Japan
Expanding Bona Fide HSCs

Guy Sauvageau , MD
Université de Montréal
Montréal,  QC, Canada
Therapeutic Applications of Expanded HSCs

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Ribosomes in Hematopoiesis and Disease

Scientific Committee on Bone Marrow Failure

Chair:

Stella M. Davies , PhD, MBBS, MRCP
Cincinnati Children's Hospital
Cincinnati,  OH

Speakers:

Kim De Keersmaecker , PhD
KU Leuven
Leuven,  Belgium
Ribosomes in Hemopoiesis and Disease

Michaela Fontenay , MD, PhD
Université de Paris, Assistance Publique-Hôpitaux de Paris
Paris,  NULL, France
Ribosome Dysfunction in Myelodysplastic Syndrome

Patrick Revy , PhD
Imagine Institute of Genetic Diseases
Paris,  France
Somatic Genetic Rescue in Shwachman-Diamond Syndrome

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Unraveling the Genetics of Bleeding: From Genotype to Phenotype

Scientific Committee on Hemostasis

Chair:

Jill M. Johnsen , MD
Bloodworks and University of Washington
Seattle,  WA

Speakers:

Keith Gomez , MD PhD
Royal Free London NHS Foundation Trust
London,  United Kingdom
High Throughput DNA Sequencing to Identify Causes of Bleeding

Samantha C. Gouw
Amsterdam University Medical Center, Netherlands
Amsterdam,  NULL, Netherlands
Genetic Causes of Hemophilia A and Risks for Inhibitor Formation

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Viral and bacterial infections - basic insights into vascular biology and coagulation

Scientific Committee on Thrombosis and Vascular Biology

Chair:

Saskia Middeldorp , MD,PhD
Radboud University
Nijmegen,  Nijmegen, Netherlands

Speakers:

Eric van Gorp , MD, PhD
Erasmus University Medical Center
Rotterdam,  NULL, Netherlands
Viral and Bacterial Infections - Basic Insights Into Vascular Biology and Coagulation

Jason S. Knight
University of Michigan
Ann Arbor,  MI
Immunothrombosis - The Interplay between Immunology and Coagulation in Infectious Disease

Katherine A. Hajjar , MD
Weill Medical College, Cornell University
New York,  NY
Endothelial Activation in Infectious Diseases