Scientific Workshops

Moderators:

Wendy Cozen , DO,MPH
University of California, Irvine
Irvine,  CA

James R. Cerhan , MD, PhD
Mayo Clinic
Rochester,  MN

Moderator:

James M. Foran , MD
Mayo Clinic Florida
Jacksonville,  FL

Speakers:

James M. Foran , MD
Mayo Clinic Florida
Jacksonville,  FL
Moderator Introduction

Kelly L Bolton , MD
Washington University In St Louis
St Louis,  MO
What Can Clonal Hematopoiesis Teach Us about Secondary Hematologic Malignancies?

Kelly L Bolton , MD
Washington University In St Louis
St Louis,  MO
Q&A

Angela Fleischman , MD, PhD
University of California, Irvine
Irvine,  CA
A Family Registry of MPN and a Potential Predictive Phenotype.

Angela Fleischman , MD, PhD
University of California, Irvine
Irvine,  CA
Q&A

Mohamed L. Sorror , MD, MSc
Fred Hutchinson Cancer Research Center
Seattle,  WA
Risk Assessment, Prediction and Decision Making for Patients with Acute Myeloid Leukemia

Mohamed L. Sorror , MD, MSc
Fred Hutchinson Cancer Research Center
Seattle,  WA
Q&A

Moderators:

Wendy Cozen , DO,MPH
USC Norris Comprehensive Cancer Center
Manhattan Beach,  CA

James R. Cerhan , MD, PhD
Mayo Clinic
Rochester,  MN

Speakers:

James R. Cerhan , MD, PhD
Mayo Clinic
Rochester,  MN
Moderator Introduction

Catherine S. Diefenbach , MD
Perlmutter Cancer Center at NYU Langone Health
New York,  NY
The Role of the Microbiome in Systemic Immunity and Lymphoma Outcome

Catherine S. Diefenbach , MD
Perlmutter Cancer Center at NYU Langone Health
New York,  NY
Q&A

Susan L. Slager , PhD
Mayo Clinic
Rochester,  MN
Risk Assessment in CLL Families: Monoclonal B-Cell Lymphocytosis Incidence and Progression to CLL

Susan L. Slager , PhD
Mayo Clinic
Rochester,  MN
Q&A

Ritu Gupta , MD
Laboratory Oncology, Dr. BRAIRCH
New Delhi,  India
Clinical Impact of Ethnic Differences on Multiple Myeloma Risk Prediction in the Era of Genomics and Novel Agents

Ritu Gupta , MD
Laboratory Oncology, Dr. BRAIRCH
New Delhi,  India
Q&A

Moderator:

Neil A. Zakai , MD,MSc
Fletcher Allen Health Care, University of Vermont
Burlington,  VT

Speakers:

Neil A. Zakai , MD,MSc
Fletcher Allen Health Care, University of Vermont
Burlington,  VT
Introduction to Benign Hematology Risk Prediction and Assessment

Rushad Patell , MBBS
Beth Israel Deaconess Medical Center
Boston,  MA
Prediction of VTE Risk in People with Cancer.

Rushad Patell , MBBS
Beth Israel Deaconess Medical Center
Boston,  MA
Q&A

Monia Marchetti
Hematology Unit, Az Osp SS Antonio e Biagio e Cesare Arrigo
Alessandria,  Italy
VTE Risk Prediction Scores in Clinical Practice Guidelines of Blood Cancers: Advantages and Pitfalls

Monia Marchetti
Hematology Unit, Az Osp SS Antonio e Biagio e Cesare Arrigo
Alessandria,  Italy
Q&A

Pamela L Lutsey , PhD, MPH
University of Minnesota
Minneapolis,  MN
Venous Thromboembolism Epidemiology: Considerations of Risk in Diverse Populations

Pamela L Lutsey , PhD, MPH
University of Minnesota
Minneapolis,  MN
Q&A

Babak Navi , MD,MS
Weill Cornell Medicine
New York,  NY
Thrombophilia and Ischemic Stroke Risk: What Does Epidemiology Teach Us

Babak Navi , MD,MS
Weill Cornell Medicine
New York,  NY
Q&A

Jordan K Schaefer , MD
University of Michigan
Ann Arbor,  MI
Pharmacoepidemiology: Antithrombotics and COVID-19 Outcomes

Jordan K Schaefer , MD
University of Michigan
Ann Arbor,  MI
Q&A

Moderators:

James M. Foran , MD
Mayo Clinic Florida
Jacksonville,  FL

Neil A. Zakai , MD,MSc
Fletcher Allen Health Care, University of Vermont
Burlington,  VT

Moderator:

Marcin Wlodarski , MD, PhD
St. Jude Children's Research Hospital
Memphis,  TN

Moderators:

Wojciech Mlynarski , Prof, MD, PhD
Medical University of Lodz
Lodz,  Poland

Richa Sharma , MD
St Jude Children's Research Hospital
Memphis,  TN

Speakers:

Edward Chew , PhD
The Walter & Eliza Hall Institute of Medical Research
Parkville,  AUS
MBD4 Associated Neoplasm Syndrome: A Tale of Blood and Guts

Edward Chew , PhD
The Walter & Eliza Hall Institute of Medical Research
Parkville,  AUS
Live Q&A

Brittany L Griffin , MS, PhD
Cleveland Clinic Foundation
Cleveland,  OH
Germline Biallelic Loss in MBD4 Leading to Early Onset AML with Hyper-Mutator Genomic Signatures

Brittany L Griffin , MS, PhD
Cleveland Clinic Foundation
Cleveland,  OH
Live Q&A

Anase Asom , BS
University of Chicago
Chicago,  IL
The Role of Germline CHEK2 Variants in Hematologic Malignancies

Anase Asom , BS
University of Chicago
Chicago,  IL
Q&A

Hannah Armes , PhD
Queen Mary University of London
London,  United Kingdom
Germline ERCC6L2 Mutations Lead to Impaired Erythropoiesis and Reshaping of the Bone Marrow Niche

Hannah Armes , PhD
Queen Mary University of London
London,  United Kingdom
Live Q&A

Agata Smogorzewska , MD
The Rockefeller University
New York,  NY
Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

Agata Smogorzewska , MD
The Rockefeller University
New York,  NY
Live Q&A

Moderators:

Julia T Warren , MD, PhD
Washington University School of Medicine
Saint Louis,  MO

Christian P. Kratz , MD
Hannover Medical School
Hannover,  Germany

Speakers:

Sara Lewis
St. Jude Children's Research Hospital
Memphis,  TN
Registry for Individuals with Germline SAMD9 and SAMD9L Mutations

Taylor Walker
University of Chicago
Chicago,  IL
Use of a Modified-Delphi Approach to Define the Pleiotropic GATA2-Deficient Phenotype for the Development of Acmg-AMP GATA2 Variant Curation Rules

Parvathy Venugopal , PhD
Centre for Cancer Biology, SA Pathology and University of South Australia
Adelaide,  Australia
Modelling a Germline Mutation to Understand Phenotypes Associated with GATA2 Deficiency Syndrome

Oded Gilad , MD
Tel Aviv University
Tel Aviv,  Israel
Syndromes Predisposing to Leukemia Are a Major Cause of Inherited Cytopenias in Children

Eunice Sindhuvi Edison , PhD
Christian Medical College
Vellore,  Tamilnadu, India
Germline Variants Contribute Significantly to the Pathogenesis of Aplastic Anemia in India

Saumya E Samaraweera , PhD
University of South Australia
Adelaide,  Australia
Childhood Acute Myeloid Leukemia Shows a High Level of Germline Predisposition

Hideki Makishima , MD, PhD
Kyoto University
Kyoto,  JPN
Predisposition and Clinical Impact of DDX41 Germline Mutations in Myeloid Neoplasms

Moderators:

Julia T Warren , MD, PhD
Washington University School of Medicine
Saint Louis,  MO

Christian P. Kratz , MD
Hannover Medical School
Hannover,  Germany

Speakers:

Christopher R. Reilly , MD
Dana-Farber Cancer Institute
Boston,  MA
Making Sense out of Missense: The Clinical and Functional Effects of Germline TERT Variants in MDS

Christopher R. Reilly , MD
Dana-Farber Cancer Institute
Boston,  MA
Live Q&A

Timothy M Chlon , PhD
Cincinnati Children's Hospital
Cincinnati,  OH
Modelling DDX41-Mutant MDS

Timothy M Chlon , PhD
Cincinnati Children's Hospital
Cincinnati,  OH
Live Q&A

Anupriya Agarwal , PhD
Oregon Health & Science University
Portland,  OR
Context-Dependent Mechanisms of Defective Hematopoiesis in RUNX1-Familial Platelet Disorder

Anupriya Agarwal , PhD
Oregon Health & Science University
Portland,  OR
Live Q&A

Moderators:

Kasiani C. Myers , MD
Cincinnati Children's Hospital
Cincinnati,  OH

Lionel Blanc , PhD
The Feinstein Institutes for Medical Research
Manhasset,  NY

Speakers:

Deena Iskander , MD
Imperial College London
London,  United Kingdom
Single-Cell Profiling of Human Bone Marrow Progenitors Reveals Mechanisms of Failing Erythropoiesis in Diamond-Blackfan Anemia

Deena Iskander , MD
Imperial College London
London,  United Kingdom
Live Q&A

Yuefeng Tang , PhD
Northwell Health
Manhasset,  NY
Conditional Deletion of Exon 2 in Rps19 Leads to Bone Marrow Failure and Absence of Stress Erythropoiesis in a Mouse Model of Diamond Blackfan Anemia

Yuefeng Tang , PhD
Northwell Health
Manhasset,  NY
Live Q&A

Senthil Velan Bhoopalan , PhD,MBBS
St. Jude Children's Research Hospital
Memphis,  TN
TP53-Dependent Hematopoietic Stem Cell Defect in RPS19 Gene-Edited CD34+ Cells

Senthil Velan Bhoopalan , PhD,MBBS
St. Jude Children's Research Hospital
Memphis,  TN
Live Q&A

Moderators:

Deepak Singhal , MBBS, MD, FRCPA, FRACP
Royal Adelaide Hospital, University of Adelaide
Adelaide,  Australia

Ana Rio-Machin , PhD
Queen Mary University of London
London,  United Kingdom

Speakers:

Patrycja M Dubielecka , PhD
Warren Alpert Medical School of Brown University
Providence, 
Whole Genome Sequencing Identifies a Recurrent Mutation in Complement Factor I in Primary Myelofibrosis

Patrycja M Dubielecka , PhD
Warren Alpert Medical School of Brown University/Rhode Island Hospital
Providence,  RI
Live Q&A

Anne Davidson , MBBS
The Feinstein Institutes for Medical Research, Northwell Health
Manhasset,  NY
Overexpression of Human TLR8 Causes Fatal Anemia in SLE-Prone Mice Byaltering the Bone Marrow Erythropoietic Niche

Anne Davidson , MBBS
The Feinstein Institutes for Medical Research, Northwell Health
Manhasset,  NY
Live Q&A

Vijay G. Sankaran , MD,PhD
Boston Children's Hospital
Boston,  MA
Insights from Rare Variant Association Studies of Myeloid Malignancies

Vijay G. Sankaran , MD,PhD
Boston Children's Hospital
Boston,  MA
Live Q&A

Julia Skokowa , MD, Ph.D.
University Hospital Tuebingen
Tuebingen,  Germany
Novel Experimental Model of Stepwise Leukemogenesis Provides Therapeutic Opportunities for Severe Congenital Neutropenia

Julia Skokowa , MD, Ph.D.
University Hospital Tuebingen
Tuebingen,  Germany
Live Q&A

Agata Karolina Pastorczak , MD, PhD
Medical University of Lodz
Lodz,  Poland
Molecular Specific Features of Diffuse Large B-Cell Lymphoma in Children with Nijmegen Breakage Syndrome

Agata Karolina Pastorczak , MD, PhD
Medical University of Lodz
Lodz,  Poland
Live Q&A

Moderator:

Lucy A. Godley , MD,PhD
Univ. of Chicago Med. Ctr.
Chicago,  IL

Speaker:

Andrew S. Artz , MD,MS
City of Hope
Duarte,  CA
Introduction

Speaker:

Paige Green , PhD, MPH,FABMR
National Cancer Institute
Bethesda,  MD
NCI Perspective and Funding Opportunities

Moderator:

Andrew S. Artz , MD,MS
City of Hope
Duarte,  CA

Speakers:

Andrew S. Artz , MD,MS
City of Hope
Duarte,  CA
Moderator Introduction

Isabel Beerman , PhD
National Institute on Aging, NIH
Baltimore,  MD
Epigenetic Analysis on Young and Aged Hematopoietic Stem Cells

Kristina Kirschner , PhD
CRUK Beatson Institute
Bearsden,  United Kingdom
Longitudinal Dynamics of Clonal Hematopoiesis Identifies Gene-Specific Fitness Effects

Moderator:

Ashley E. Rosko , MD
The Ohio State University
Columbus,  OH

Speakers:

Ashley E. Rosko , MD
The Ohio State University
Columbus,  OH
Moderator Introduction

Curtis J Henry , PhD
Emory University School of Medicine
Atlanta,  GA
Delineating the Impact of Interleukin-37 on Anti-Cancer Immunity in Aged Backgrounds

Amina Abdul-Aziz , PhD
University of Cincinnati
Cincinnati,  OH
Senescence and Aging in the AML Microenvironment

Michaela R Reagan , PhD
Maine Medical Center Research Institute
South Portland,  ME
Bone Marrow Adipocytes in Aging and Multiple Myeloma

Moderators:

Heidi D. Klepin , MD,MS
Wake Forest School of Medicine
Winston Salem,  NC

Shakira J. Grant , MBBS
The University of North Carolina at Chapel Hill
Chapel Hill,  NC

Speakers:

Shakira J. Grant , MBBS
Pennsylvania Hospital
Chapel Hill,  NC
Moderator Introduction

Reinhard Stauder , MD
Innsbruck Medical University
Innsbruck,  Austria
Integration of Patient-Reported and Patient-Oriented Factors in Health Care of Older Patients with Myelodysplastic Syndromes

Philip H. Imus , MD
Columbia University
Baltimore,  MD
Aging, Myeloid Recovery, and Resilience after Allogeneic BMT

Alessandra Tucci , MD
Department of Hematology, ASST Spedali Civili
Brescia,  Italy
Prognostication By Geriatric Assessment in Hodgkin Lymphoma

Lisa K. Hicks , MD, MSc
Co-Chair of the ASH RC COVID-19 Registry Malignant Task Force
D.C.,  WA
Exploring the Impact of Advanced Age on COVID19 Outcomes and Treatment Patterns in the ASH RC COVID-19 Malignant Registry

Moderator:

Heidi D. Klepin , MD,MS
Wake Forest School of Medicine
Winston Salem,  NC

Speaker:

Heidi D. Klepin , MD,MS
Wake Forest School of Medicine
Winston Salem,  NC
Closing Remarks

Moderators:

Shannon M. Bates , MD,FRCPC,MSc
McMaster University
Hamilton,  ON, Canada

Irina Murakhovskaya , MD
Montefiore Hospital, Albert Einstein College of Medicine
Bronx,  NY

Henny H. Billett , MD, MSc
Montefiore Medical Center, Albert Einstein College of Medicine
Bronx,  NY

Moderator:

Shruti Chaturvedi , MBBS
Johns Hopkins University School of Medicine
Baltimore,  MD

Speakers:

Shruti Chaturvedi , MBBS
Johns Hopkins University School of Medicine
Baltimore,  MD
Moderator Introduction

Bruno Fattizzo , MD
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico e Università degli Studi
Milan,  Italy
Autoimmune Hemolytic Anemia in Pregnancy

Fadi Fakhouri
University of Lausanne
Lausanne,  Switzerland
AHUS and Pregnancy

Shruti Chaturvedi , MBBS
Johns Hopkins University School of Medicine
Baltimore,  MD
Emerging Evidence on Preeclampsia and APLS

Moderator:

Menaka Pai , BSc,MD,FRCPC,MSc
McMaster University
Hamilton,  Canada

Speakers:

Menaka Pai , BSc,MD,FRCPC,MSc
McMaster University
Hamilton,  ON, Canada
Moderator Introduction

A. Kinga Malinowski , MD
Mt. Sinai Hospital
Toronto,  ON, Canada
Hematologic Aspects of COVID in Pregnancy

Menaka Pai , BSc,MD,FRCPC,MSc
McMaster University
Hamilton,  ON, Canada
Hematologic Complications of COVID Vaccination

Moderator:

Henny H. Billett , MD, MSc
Montefiore Medical Center, Albert Einstein College of Medicine
Bronx,  NY

Speakers:

Henny H. Billett , MD, MSc
Montefiore Medical Center, Albert Einstein College of Medicine
Bronx,  NY
Moderator Introduction

Craig D. Seaman
University of Pittsburgh
Pittsburgh,  PA
Next Generation Sequencing and Non-Invasive Prenatal Testing

Lani Lieberman , MD
University of Toronto
Toronto,  ON, Canada
Fetal and Neonatal Alloimmune Thrombocytopenia

David Stitelman , MD
Yale School of Medicine
New Haven,  CT
Prenatal Gene Therapy in Hematologic Disorders

Moderators:

Irina Murakhovskaya , MD
Montefiore Hospital, Albert Einstein College of Medicine
Bronx,  NY

Shannon M. Bates , MD,FRCPC,MSc
McMaster University
Hamilton,  ON, Canada

Moderators:

Lisa Baumann Kreuziger , MD
Versiti Blood Center of Wisconsin
Menomonee Falls,  WI

Jeffrey I. Zwicker , MD
Beth Israel Deaconess Medical Center Harvard Medical School
Boston,  MA

Moderators:

Alisa S. Wolberg , PhD
University of North Carolina At Chapel Hill
Chapel Hill,  NC

Christophe Dubois
Aix Marseille Universit%26#X00e9;
Marseille,  France

Speakers:

Alisa S. Wolberg , PhD
University of North Carolina At Chapel Hill
Chapel Hill,  NC
Moderator Introduction

Westrick J Randal , PhD
Oakland University
rochester hills,  MI
PAI-2 Deficiency and Accelerated Tumor Growth .

Westrick J Randal , PhD
Oakland University
rochester hills,  MI
Q&A

Paul Jurasz
University of Alberta
Edmonton,  AB, Canada
Platelets and Pdl-1

Paul Jurasz
University of Alberta
Edmonton,  AB, Canada
Q&A

Claudine S Bonder , PhD
Hanson Institute, Institute of Medical and Veterinary Science
Adelaide,  SA, Australia
Platelets and Vasculogenic Mimicry By Cancer Cells

Claudine S Bonder , PhD
University of South Australia
Adelaide,  SA, Australia
Q&A

Moderators:

Mary Cushman , MD
Larner College of Medicine at the University of Vermont
Colchester,  VT

Cihan Ay
Medical University of Vienna
Vienna,  Austria

Speakers:

Mary Cushman , MD
Larner College of Medicine at the University of Vermont
Colchester,  VT
Moderator Introduction

Nadim Tawil , PhD
McGill University
Montreal,  QC, Canada
Podoplanin and Procoagulant Extracellular Vesicles in Glioma

Nadim Tawil , PhD
McGill University
Montreal,  QC, Canada
Q&A

Simon Mantha , MD,MPH
Memorial Sloan Kettering Cancer Center
New York,  NY
Genomic Profiling and Thrombosis in Cancer

Simon Mantha , MD,MPH
Memorial Sloan Kettering Cancer Center
New York,  NY
Q&A

Marc Carrier , MD
University of Ottawa
Ottawa,  ON, Canada
Growth Differentiation Factor-15 and Bleeding in Cancer

Marc Carrier , MD
University of Ottawa
Ottawa,  ON, Canada
Q&A

Moderators:

Ayalew Tefferi , MD
Mayo Clinic
Rochester,  MN

Casey L. O'Connell , MD
University of Southern California
Los Angeles,  CA

Speakers:

Casey L. O'Connell , MD
University of Southern California
Los Angeles,  CA
Moderator Introduction

Anish V. Sharda , MBBS
Harvard Medical School
Brookline,  MA
Protein Disulfide Isomerase and Thrombosis in MPN

Anish V. Sharda , MBBS
Harvard Medical School
Brookline,  MA
Q&A

Radhika Gangaraju , MD
University Of Alabama
Birmingham,  AL
HIF-Regulated Genes and Thrombosis in MPN

Radhika Gangaraju , MD
University Of Alabama
Birmingham,  AL
Q&A

Anandi Krishnan , PhD
Stanford University School of Medicine
Palo Alto,  CA
Thromboinflammatory Signatures in MPN

Anandi Krishnan , PhD
Stanford University School of Medicine
Palo Alto,  CA
Q&A

Moderators:

Lisa Baumann Kreuziger , MD
Versiti, Blood Research Institute
Milwaukee,  WI

Jeffrey I. Zwicker , MD
Beth Israel Deaconess Medical Center Harvard Medical School
Boston,  MA

Speakers:

Jeffrey I. Zwicker , MD
Beth Israel Deaconess Medical Center Harvard Medical School
Boston,  MA
Moderator Introduction

Yohei Hisada , Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill,  NC
Mechanisms of Hypercoagulability in Different Types of Acute Leukemia: Roles of Tissue Factor-Positive and Phosphatidylserine-Positive Extracellular Vesicles

Yohei Hisada , Ph.D.
University of North Carolina At Chapel Hill
Chapel Hill,  NC
Q&A

Alok A Khorana , MD
CLEVELAND CLINIC - US
Cleveland,  OH
Biomarker Signatures in Cancer Patients with and without Venous Thromboembolism Events: A Substudy of Cassini

Alok A Khorana , MD
CLEVELAND CLINIC - US
Cleveland,  OH
Q&A

Ana Luisa Palacios-Acedo , MD,MSc
Aix-Marseille Université
Marseille,  France
Tipping the Hemostatic Balance in Cancer: A Multi-Player Game

Ana Luisa Palacios-Acedo , MD,MSc
Aix-Marseille Université
Marseille,  France
Q&A

Moderators:

Jeffrey I. Zwicker , MD
Beth Israel Deaconess Medical Center Harvard Medical School
Boston,  MA

Lisa Baumann Kreuziger , MD
Versiti Blood Center of Wisconsin
Menomonee Falls,  WI

Moderators:

Ross L. Levine , MD
Memorial Sloan Kettering Cancer Center
New York,  NY

Patricia Ernst , PhD
University of Colorado Denver, Anschutz Medical Campus
Aurora,  CO

Moderator:

Eric Pietras , PhD
University of Colorado
Aurora,  CO

Speakers:

Eric Pietras , PhD
University of Colorado
Aurora,  CO
Moderator Introduction

Yoon-A Kang , PhD
Washington University School of Medicine
St. Louis,  MO
Secretory MPP3 Reinforce Myeloid Differentiation Trajectory and Amplify Myeloid Cell Production

Yoon-A Kang , PhD
Washington University School of Medicine
New York,  NY
Q&A

Robert Signer , PhD
UC San Diego
La Jolla,  CA
Crosstalk between Autophagy and the Proteasome Coordinates Hematopoietic Stem Cell Quiescence, Proteostasis and Cell Fate Determination

Robert Signer , PhD
Moores Cancer Center
La Jolla,  CA
Q&A

Kevin Rouault-Pierre , PhD
Barts Cancer Institute, Queen Mary University of London
London,  United Kingdom
SF3B1 Mutation in Myelodysplasia Induces Depletion of Key Substrates of the Heme Synthesis

Kevin Rouault-Pierre , PhD
Barts Cancer Institute, Queen Mary University of London
London,  United Kingdom
Q&A

Katie L Kathrein , PhD
University of South Carolina
Columbia,  SC
Ing4-Deficiency Enhances Hematopoietic Stem Cell Quiescence and Confers Resistance to Inflammatory Stress

Katie L Kathrein , PhD
University of South Carolina
Columbia,  SC
Q&A

Moderator:

Ulrich G. Steidl , MD,PhD
Albert Einstein College of Medicine
Bronx,  NY

Speakers:

Ulrich G. Steidl , MD,PhD
Albert Einstein College of Medicine
Bronx,  NY
Moderator Introduction

Nina Cabezas-Wallscheid , PhD
Max-Planck-Institute of Immunobiology and Epigenetics
Freiburg,  Germany
Multilayer-Omics Analysis Reveals a Non-Classical Retinoic Acid Receptor Signaling Axis That Regulates Hematopoietic Stem Cell Identity

Nina Cabezas-Wallscheid , PhD
Max-Planck-Institute of Immunobiology and Epigenetics
Freiburg,  Germany
Q&A

Vikram R Paralkar , MD
University of Pennsylvania
Philadelphia,  PA
An Atlas of Hematopoietic Transcription Factor Binding to rDNA Reveals a Role for CEBPA in rRNA Regulation

Vikram R Paralkar , MD
University of Pennsylvania
Philadelphia,  PA
Q&A

Kristy Stengel , PhD
Albert Einstein College of Medicine
Bronx,  NY
Targeted Transcription Factor Degradation Defines Gene Networks and Mechanism of Action

Kristy Stengel , PhD
Albert Einstein College of Medicine
Bronx,  NY
Q&A

Stanley C Lee , PhD
Fred Hutchinson Cancer Research Center
Seattle,  WA
Spliceosome Mutant Leukemias Are Preferentially Sensitive to PARP1 Inhibition

Stanley C Lee , PhD
Fred Hutchinson Cancer Research Center
Seattle,  WA
Q&A

Moderator:

Benjamin L. Ebert , MD
Department of Medical Oncology, Dana-Farber Cancer Institute
Boston,  MA

Speakers:

Benjamin L. Ebert , MD
Department of Medical Oncology, Dana-Farber Cancer Institute
Boston,  MA
Moderator Introduction

Shruti Bhatt , PhD
National University of Singapore
Singapore,  Singapore
Unraveling Basis of Resistance to Acute Myeloid Leukemia Therapy

Shruti Bhatt , PhD
National University of Singapore
Singapore,  Singapore
Q&A

Liling Wan , PhD
University of Pennsylvania
Philadelphia,  PA
Targeting Chromatin Reader-Mediated Transcriptional Programs in Acute Myeloid Leukemia.

Liling Wan , PhD
University of Pennsylvania
Philadelphia,  PA
Q&A

Julie-Aurore Losman , MD, PhD
Dana Farber Cancer Institute
Boston,  MA
R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Tumorigenesis in IDH-Mutant Cancers

Julie-Aurore Losman , MD, PhD
Dana Farber Cancer Institute
Boston,  MA
Q&A

Paolo Gallipoli , MD
University of Cambridge
London,  United Kingdom
Leveraging Metabolic Dependencies to Overcome Therapy Resistance in AML

Paolo Gallipoli , MD
University of Cambridge
London,  United Kingdom
Q&A

Moderator:

Claudia Lengerke , MD
University Hospital Tübingen
Tübingen,  Germany

Speakers:

Claudia Lengerke , MD
University Hospital Tübingen
Tübingen,  Germany
Moderator Introduction

Courtney L Jones , PhD
University of Toronto
Toronto,  ON, Canada
SIRT3 Inhibition Targets Leukemia Stem Cells By Disrupting Lipid Metabolism

Courtney L Jones , PhD
University of Toronto
Toronto,  ON, Canada
Q&A

Raajit Rampal , MD, PhD
Memorial Sloan Kettering Cancer Institute
New York,  NY
BMP/SMAD Pathway As a Mediator of Leukemic Transformation of Tp53 Mutant MPNs

Raajit Rampal , MD, PhD
Memorial Sloan Kettering Cancer Institute
New York,  NY
Q&a

Shannon McKinney-Freeman , PhD
St. Jude Children's Research Hospital
Memphis,  TN
Murine Fetal Bone Marrow Does Not Support Functional Hematopoietic Stem and Progenitor Cells until Birth

Shannon McKinney-Freeman , PhD
St. Jude Children's Research Hospital
Memphis,  TN
Q&A

Jan-Henning Klusmann , MD
University Hospital Frankfurt
Frankfurt (Main),  Germany
A Fetal Origin of Leukemia: Deciphering the Role of RUNX1 Isoforms in Trisomy 21 Associated Leukemogenesis

Jan-Henning Klusmann , MD
University Hospital Frankfurt
Frankfurt (Main),  Germany
Q&A

Moderators:

Patricia Ernst , PhD
University of Colorado Denver, Anschutz Medical Campus
Aurora,  CO

Ross L. Levine , MD
Memorial Sloan Kettering Cancer Center
New York,  NY

Moderator:

Fangxin Hong , PhD
Pfizer
Cambridge,  MA

Moderators:

Willem E. Fibbe , MD
Leiden Univ. Medical Ctr.
Leiden,  Netherlands

Jeffrey Weitz
McMaster University
Hamilton,  ON, Canada

Speakers:

Willem E. Fibbe , MD
Leiden Univ. Medical Ctr.
Leiden,  Netherlands
Moderator Introduction

Richard F. Little , MD,MPH
National Cancer Institute
Washington,  DC
Streamlining and Prioritizing Clinical Trials – Overview

Yoji Sato , PhD
National Institute of Health Sciences
Kawasaki,  Japan
Regulatory Perspective - International

Angelo De Claro , MD
US Food and Drug Administration
Bethesda,  MD
Regulatory Perspective - US

Malte Peters , MD
Morphosys AG
Planegg,  Bavaria, Germany
Industry Perspective

Moderators:

Alex F. Herrera , MD
City of Hope
Duarte,  CA

Sonali M. Smith , MD
University of Chicago
Chicago,  IL

Speakers:

Alex F. Herrera , MD
City of Hope
Duarte,  CA
Moderator Introduction

David P. Steensma , MD
Novartis Institutes of Biomedical Research
Cambridge,  MA
Enhance the Interplay between Pre-Clinical and Clinical Research - from Bench to Bedside

Kannan Natarajan , PhD
Pfizer Inc.
Peapack,  NJ
Better Data Is Key

Megan Othus , PhD
Fred Hutchinson Cancer Research Center
Seattle,  WA
Innovative Trial Design

Moderators:

Kristen M. Sanfilippo , MD
Washington University in St. Louis School of Medicine
Chesterfield,  MO

Neil Goldenberg , MD,PhD
All Children's Hospital Johns Hopkins Medicine
Saint Petersburg,  FL

Speakers:

Kristen M. Sanfilippo , MD
Washington University in St. Louis School of Medicine
Chesterfield,  MO
Moderator Introduction

Uma Borate , MD
The Ohio State University
Columbus,  OH
Expediting Time from Concept to Enrollment

Ryan Zarychanski , MD,MSc,FRCPC
Cancercare Manitoba University of Manitoba
Winnipeg,  MB, Canada
Novel Methods in Trial Design and Global Collaboration: Lessons from COVID-19 That Are Relevant to Patients with Hematologic Disorders

Jean M Connors , MD
Brigham %26 Women's Hosp./Dana Farber Cancer Inst.
Boston,  MA
Prioritizing the Patients - Patients Are a Virtue

Moderator:

Fangxin Hong , PhD
Pfizer
Cambridge,  MA

Moderators:

Stefano Rivella , PhD
Children’s Hospital of Philadelphia
Philadelphia,  PA

Mitchell J. Weiss , MD, Ph.D
St. Jude Children’s Research Hospital
Memphis,  TN

Moderators:

Alexis A. Thompson , MD, MPH
Northwestern University
Chicago,  IL

Giuliana Ferrari , PhD
San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute
Milan,  Italy

Speakers:

Giuliana Ferrari , PhD
San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute
Milan,  Italy
Moderator Introduction

Wendy W Pang , MD,PhD
Jasper Therapeutics, Inc
Redwood City,  CA
Potential Alternatives to Myeloablative Chemotherapy Conditioning

Punam Malik , MD
Cincinnati Children's Hosp.
Cincinnati,  OH
Gamma-Globin Gene Addition

Annarita Miccio , PhD
Université de Paris, Imagine Institute, Laboratory of chromatin and gene regulation during development, INSERM UMR1163, 75015
Paris,  France
Creating HPFH Via Editing

Laura Breda , PhD
The Children's Hospital of Philadelphia
Philadelphia,  PA
Novel Vector Modifications to Improve Synthesis of Curative Hemoglobins

Moderators:

John F. Tisdale , MD
National Institutes of Health
Bethesda,  MD

Linzhao Cheng , PhD
University of Science and Technology of China
Hefei,  China

Speakers:

Linzhao Cheng , PhD
University of Science and Technology of China
Hefei,  China
Moderator Introduction

Lachelle D. Weeks , MD,PhD
Dana Farber Cancer Institute
Boston,  MA
Development and Identification of Clonal Hematopoiesis

Courtney D. Fitzhugh , MD
NIH (Hematology)
Bethesda,  MD
Clonal Hematopoiesis in SCD

Shengdar Q. Tsai , PhD
St. Jude Children's Research Hospital
Memphis,  TN
Genotoxicities Associated with Genome Editing, Including SCD

Peter W. Marks , MD, PhD
FDA
Washington,  DC
FDA Position on Addressing Genome Toxicities in SCD Related Gene Therapy Trials

Moderators:

Matthew H. Porteus , MD, PhD
Stanford Medical School
Stanford,  CA

Kim Smith-Whitley , MD
Children's Hospital of Philadelphia
Philadelphia,  PA

Speakers:

Kim Smith-Whitley , MD
Children's Hospital of Philadelphia
Philadelphia,  PA
Moderator Introduction

Gerd A. Blobel , MD, PhD
Children's Hospital of Philadelphia
Philadelphia,  PA
Targeting the HbF Pathway

Jonathan S Yen , PhD
St. Jude Children's Research Hospital
Memphis,  TN
Base Editing for SCD

Andre Lieber , MD, PhD
University of Washington
Seattle,  WA
In Vivo Gene Editing for SCD

Donna S. Neuberg , ScD
Dana-Farber Cancer Institute
Boston,  MA
ASH Real World Evidence (RWE) Initiative on SCD

Moderators:

Stefano Rivella , PhD
Children’s Hospital of Philadelphia
Philadelphia,  PA

Mitchell J. Weiss , MD, Ph.D
St. Jude Children’s Research Hospital
Memphis,  TN

Moderators:

Piers Blombery , MBBS
Peter MacCallum Cancer Centre
Melbourne,  Australia

Torsten Haferlach , MD
MLL Munich Leukemia Laboratory
Munich,  Germany

Moderator:

Torsten Haferlach , MD
MLL Munich Leukemia Laboratory
Munich,  Germany

Speakers:

Torsten Haferlach , MD
MLL Munich Leukemia Laboratory
Munich,  Germany
Moderator Introduction

Wendy N. Erber , MD,PhD,FRCPA,FRCPath,MBA
University of Western Australia
Crawley W.A.,  WEA, Australia
Chromosomal Analysis of Immunophenotyped Cells in Suspension By Imaging Flow Cytometry (“Immuno-flowFISH”)

Aziz Nazha
Amazon Web Services
Cleveland,  OH
Artificial Intelligence in Diagnostic Hematology

Linda B Baughn , PhD
Mayo Clinic
Rochester,  MN
Detection of Structural Variants and Copy Number Abnormalities By NGS in Hematologic Malignancies: Is It Time to Replace FISH and Chromosomes?

Moderator:

David M. Kurtz , MD,PhD
Stanford University
Stanford,  CA

Speakers:

David M. Kurtz , MD,PhD
Stanford University
Stanford,  CA
Moderator Introduction

David M. Kurtz , MD,PhD
Stanford University
Stanford,  CA
Novel Technologies in Circulating Tumor DNA

Imogen Caldwell , MBBS
Peter MacCallum Cancer Centre
Melbourne,  VIC, Australia
Circulating Tumor DNA Measurements Correlate with Disease Burden and Response in Patients Undergoing CAR T-Cell Therapy

Piers Blombery , MBBS
Peter MacCallum Cancer Centre
Melbourne,  Australia
Case Presentations - Clinical Utility of Circulating Tumor DNA in the Real World?

Moderator:

Ella R Thompson , PhD, BSc
Peter MacCallum Cancer Centre
Melbourne,  Australia

Speakers:

Ella R Thompson , PhD, BSc
Peter MacCallum Cancer Centre
Melbourne,  VIC, Australia
Moderator Introduction

Andrew H. Wei , MBBS,PhD
The Alfred Hospital
Melbourne,  VIC, Australia
MRD Directed Therapy - a New Frontier in AML

Ing-Soo Tiong
Peter MacCallum Cancer Centre
Melbourne,  VIC, Australia
Ultra-Deep NGS for MRD Assessment in CEBPA Mutated AML

Michael Heuser , MD
Hannover Medical School
Hannover,  Germany
Standardization of NGS-MRD

Moderator:

Kilannin Krysiak , PhD
Washington University In St Louis
Saint Louis,  MO

Speakers:

Kilannin Krysiak , PhD
Washington University In St Louis
Saint Louis,  MO
Moderator Introduction

Malachi Griffith , PhD
Washington University in St. Louis
St. Louis,  MO
A Clinical Genome Resource for Somatic Variant Interpretation in Cancer

Jennelle C. Hodge , PhD
Indiana University
Indianapolis,  IN
The Compendium of Cancer Genome Aberrations (CCGA): Becoming a Global Hub for WHO Classification of Tumours-Based Clinical Cancer Interpretation

Daniel MacArthur
Garvan Institute of Medical Research
Darlinghurst,  NSW, Australia
Creating Global Harmonized Resources for Understanding Population Genetic Variation

Moderators:

Piers Blombery , MBBS
Peter MacCallum Cancer Centre
Melbourne,  Australia

Torsten Haferlach , MD
MLL Munich Leukemia Laboratory
Munich,  Germany

Moderators:

Stephen M. Ansell , MD, PhD
Mayo Clinic
Rochester,  MN

Ronald Levy , MD
Stanford Univ. School of Medicine
Stanford,  CA

Moderators:

Stephen M. Ansell , MD, PhD
Mayo Clinic
Rochester,  MN

Ronald Levy , MD
Stanford Univ. School of Medicine
Stanford,  CA

Speakers:

Stephen M. Ansell , MD, PhD
Mayo Clinic
Rochester,  MN
Moderator Introduction

Natalie S Grover , MD
University of North Carolina at Chapel Hill
Chapel Hill,  NC
Current Results with CD30 CAR T-Cells in Hodgkin Lymphoma

Natalie S Grover , MD
University of North Carolina at Chapel Hill
Chapel Hill,  NC
Q&A

Graham P. Collins , MD, DPhil
Oxford University Hospitals NHS Foundation Trust
Oxford,  ENG, United Kingdom
Current Results with Camidanlumab Tesirine (Cami) in Hodgkin Lymphoma

Graham P. Collins , MD, DPhil
Oxford University Hospitals NHS Foundation Trust
Oxford,  ENG, United Kingdom
Q&A

Moderators:

Ronald Levy , MD
Stanford Univ. School of Medicine
Stanford,  CA

Stephen M. Ansell , MD, PhD
Mayo Clinic
Rochester,  MN

Speakers:

Ronald Levy , MD
Stanford Univ. School of Medicine
Stanford,  CA
Moderator Introduction

Crystal L. Mackall , MD
Stanford University School of Medicine
Stanford,  CA
Dual Targeted CAR T-Cells in B-Cell Lymphoma

Crystal L. Mackall , MD
Stanford University School of Medicine
Stanford,  CA
Q&A

Martin Hutchings
Rigshospitalet
Copenhagen,  Denmark
Bispecific Antibodies with Increased Target Binding – Does It Matter?

Martin Hutchings
Rigshospitalet
Copenhagen,  Denmark
Q&A

Moderators:

Stephen M. Ansell , MD, PhD
Mayo Clinic
Rochester,  MN

Ronald Levy , MD
Stanford Univ. School of Medicine
Stanford,  CA

Speakers:

Ronald Levy , MD
Stanford Univ. School of Medicine
Stanford,  CA
Moderator Introduction

LaQuisa C. Hill , MD
Baylor College of Medicine, Houston Methodist Hospital
Houston,  TX
Current Results with CD5/7/30 CAR T-Cells for T-Cell Lymphoma

LaQuisa C. Hill , MD
Baylor College of Medicine, Houston Methodist Hospital
Houston,  TX
Q&A

Paola Ghione , MD
Roswell Park Comprehensive Cancer Center
Buffalo,  NY
Immunotherapy in T-Cell Lymphomas – Targeting T-Cells and Macrophages

Paola Ghione , MD
Roswell Park Comprehensive Cancer Center
Buffalo,  NY
Q&A

Moderators:

Ronald Levy , MD
Stanford Univ. School of Medicine
Stanford,  CA

Stephen M. Ansell , MD, PhD
Mayo Clinic
Rochester,  MN