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ASH Issues Recommendations for Pediatric Research Questions to NIH’s All of Us Research Program

ASH submitted comments to the National Institutes of Health (NIH) on hematology-related pediatric research that should be included in the NIH's All of Us research program. ASH’s recommendations include: (1) improving genomic profiling and annotation of genomic variants; (2) elucidating the impact of epigenetic modifications on disease progression; (3) evaluating promising biomarker candidates for prevention and treatment of disease; (4) elucidating the specific impact of pain on children and their responses to interventions; and (5) permitting assessment of the clinical use of this data. ASH’s recommendations were developed with input from various scientific committee members and built on the Society’s research agenda and sickle cell disease research priorities.