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Milestones in Antiplatelet Therapy

An article on antiplatelet therapy by Andrew I. Schafer, MD, and these accompanying milestones were published in December 2008 as part of the special ASH anniversary brochure, 50 Years in Hematology: Research That Revolutionized Patient Care.

1882 Giulio Bizzozero describes blood platelets.
1953 Lawrence Craven reports that aspirin prevents heart attacks.
1960s Harvey Weiss, Sir John Vane, Philip Majerus, Gerald Roth, and others elucidate the antiplatelet actions of aspirin.
1970s Alan T. Nurden, Jacques P. Caen, David R. Phillips, and others describe the molecular basis of platelet aggregation.
1994 Barry Coller's monoclonal antibody to platelet GP IIb/IIIa is approved for use in coronary angioplasty.
1998 ADP receptor antagonists are shown to be effective antiplatelet agents in preventing coronary stent thrombosis.