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About ASH

Scientific Committee on Myeloid Biology

Committee Roster

Chair
Sandra  S. Zinkel, MD, PhD  ('20)

Vice Chair
Marie-Dominique Filippi, PhD  ('20)

Appointed Members
Alan  D. Friedman, MD  ('22)
Patricia  C. Fulkerson, MD,PhD  ('20)
Yun Huang, PhD  ('23)
Jeffrey  A. Magee, MD,PhD  ('22)
Esther  A. Obeng, MD,PhD  ('23)
Laura  G. Schuettpelz, MD, PhD  ('20)
Daniel  G. Tenen, MD  ('20)
Fabiola Traina, MD, PhD  ('20)

Committee Mandate

The Scientific Committee on Myeloid Biology is focused on scientific aspects of normal myeloid biology and myelopoiesis, including neutrophils, monocytes, eosinophils, and basophils. The focus of this committee will include:

The clinical areas:

  1. Neutropenia (severe congenital neutropenia, cyclic neutropenia, chronic benign neutropenia, neutropenia associated with immunodeficiencies, Shwachman Diamond Syndrome)
  2. Neutrophil function defects (chronic granulomatous disease, leukocyte adhesion disorders, Chediak Higashi syndrome, myeloperoxidase deficiency)
  3. Eosinophilia (Idiopathic Hypereosinophilia syndrome, nonidiopathic)
  4. Mast cell disorders
  5. Inflammatory diseases

The Methodological aspects:

  1. Studying myelopoiesis and myeloid function (in vivo and in vitro models)
  2. Understanding the basis of myeloid diseases
  3. Understanding the heterogeneity of inflammasomes and other myeloid populations
  4. Systems biological approaches to interrogate regulatory networks, phagocytosis, adhesion, and other aspects of myeloid cell biology

The emerging areas:

  1. New therapies
  2. Signaling and regulatory pathways
  3. Genomics/proteomics/systems biology

There is potential overlap with:

  1. Blood Disorders in Childhood – congenital syndromes
  2. Hematopoiesis – myeloid growth factors
  3. Myeloid Neoplasia – myeloid leukemia, myeloproliferative disorders, myelodysplastic syndrome, transformation in myeloid progenitors
  4. Stem Cells and Regenerative Medicine – myeloid stem cells
  5. Immunology and Host Defense-differentiation and function of immune cells (including monocytes macrophages, eosinophils, and myeloid derived suppressor cells)
  6. Bone Marrow Failure-inherited and acquired neutropenia

Thus, appropriate sessions at the annual meeting may include:

  • Neutropenia – basic, translational, therapies
  • Neutrophil function defects – basic, translational, therapies
  • Regulatory pathways that govern myeloid differentiation
  • Studies of myeloid cell function
  • Inherited and acquired disorders of eosinophils, monocytes, and mast cells
  • The committee will consider developing joint sessions with other scientific committees with shared scientific interests.

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