The American Society of Hematology (ASH) has recently updated its Sickle Cell Disease (SCD) Research Priorities, reflecting advancements made over the past five years. These updates will serve as a crucial guide for SCD researchers over the next five years. The research listed includes remaining unaddressed questions and specific research topics that could push toward the goal of curing SCD. The priorities are not listed in rank order. ASH encourages the Sickle Cell Disease (SCD) stakeholder community to adopt multidisciplinary strategies to advance these critical areas. By embracing a collaborative approach, advancements can be delivered to patients more quickly, cost-effectively, and efficiently to help alleviate the burden of Sickle Cell Disease.