ASH ALL in AYAs Guidelines: Relapse/Refractory Management

Over recent years, relapsed or refractory acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYAs) has been recognized as a distinct clinical challenge, with resistance to initial therapy and increasing use of novel immunotherapies and transplant‑based strategies. The purpose of these guidelines is to provide evidence‑based recommendations to guide treatment decisions for AYAs with relapsed or refractory ALL.

Guideline Implementation Tools and Resources

Visual Summary

This concise visual aid is intended to support understanding of the recommendations and to aid in clinical decision-making:

Teaching Slides

Educational slide sets to teach about relapse/refractory management of ALL in AYAs.

Pocket Guide

This brief, evidence-based pocket guide is intended to help physicians provide quality care to patients.

What is ALL?

Infographic to better understand ALL in AYAs, including its risks, symptoms, and treatment options