Over recent years, expanding experience with transfusion therapy in sickle cell disease (SCD) has highlighted both its central role in preventing and treating organ damage and the need for careful, standardized practice to minimize risks. The ASH Clinical Practice Guidelines on SCD-related transfusion support provide evidence-based recommendations on when and how transfusions should be used, including guidance on extended red blood cell matching, use of immunosuppressive strategies in high-risk situations, red cell exchange for severe complications, chronic transfusion programs, and perioperative management.
