Milestones in Antiplatelet Therapy
An article on antiplatelet therapy by Andrew I. Schafer, MD, and these accompanying milestones were published in December 2008 as part of the special ASH anniversary brochure, 50 Years in Hematology: Research That Revolutionized Patient Care.
| 1882 | Giulio Bizzozero describes blood platelets. |
| 1953 | Lawrence Craven reports that aspirin prevents heart attacks. |
| 1960s | Harvey Weiss, Sir John Vane, Philip Majerus, Gerald Roth, and others elucidate the antiplatelet actions of aspirin. |
| 1970s | Alan T. Nurden, Jacques P. Caen, David R. Phillips, and others describe the molecular basis of platelet aggregation. |
| 1994 | Barry Coller's monoclonal antibody to platelet GP IIb/IIIa is approved for use in coronary angioplasty. |
| 1998 | ADP receptor antagonists are shown to be effective antiplatelet agents in preventing coronary stent thrombosis. |