Meetings

Scientific Spotlight Sessions

The Scientific Spotlight Sessions are intended to provide an in-depth review on specific scientific topics. This year, speakers will discuss the role of oxidative signaling processes in the development and treatment of thrombosis.

Each 90-minute session will be presented once in a small-venue format on either Sunday or Monday and will include ample time for audience questions and participation. These sessions are restricted to medical and research professionals only; no businesspersons or media will be admitted.

Redox Biology in Thrombosis

Monday, December 9, 2019, 10:30 a.m. - 12:00 p.m.
Orange County Convention Center, W307, Level 3

Reactive oxygen species (ROS) and redox biology has received significant attention in vascular biology. However, ROS production by, and influences on, platelet function has received less attention than its interactions with other cells in the vasculature. Platelets both produce and respond to ROS. This session will discuss how ROS signaling regulates platelet function in ischemic pathologies. In addition, the use of ROS scavengers will be explored as a therapeutic strategy to ameliorate platelet destruction.

Dr. Craig Morrell will focus on mechanisms of platelet signaling in response to endogenous and exogenous ROS. Furthermore, he will discuss how ROS changes the platelet proteome independent of the megakaryocyte. These data will be placed in the context of ischemic vascular pathologies, including peripheral artery disease.

Dr. Karen Vanhoorelbeke will discuss the efficacy of N-acetyl cysteine (NAC) in the treatment of immune mediated thrombotic thrombocytopenia purpura (TTP) as tested in animal models. In addition, literature and clinical trials where NAC has been used to treat TTP patients will be reviewed. Finally, novel data on the role of anti-ADAMTS13 autoantibodies in immune-mediated TTP will be discussed.

Co-Chairs:

Craig N. Morrell
University of Rochester
Rochester, NY

Karen Vanhoorelbeke, PhD
Katholieke Universiteit Leuven
Leuven, Belgium

Speakers:

Craig N. Morrell
University of Rochester
Rochester, NY
Oxidative Signaling in Platelets

Karen Vanhoorelbeke, PhD
Katholieke Universiteit Leuven
Leuven, Belgium
N-acetylcysteine for Thrombotic Thrombocytopenic Purpura

Other Scientific Sessions

  • Scientific Program

    A complete list of sessions from the ASH Scientific Program 

  • Continuing Conversations With the Speakers

    Informal discussions with Scientific Program speakers, designed to provide increased access to information on a specific topic and to the opinions of experts

  • Special Scientific Symposia

    Symposia highlighting transformative research with implications for research and clinical practice across the field of hematology

  • Meet the Scientist

    Sessions designed to provide an opportunity for a small number of attendees to meet with a scientific expert in a setting that fosters interaction

  • Friday Scientific Workshops

    Held the day before the ASH annual meeting, these workshops feature interactive discussions of the latest science developments in a particular field of hematology