- Perioperative Bridging Is Falling DownSeptember 01, 2015 | Adam Cuker, MD, MS
Dr. Cuker talks about the BRIDGE trial, which looks at the practice of perioperative bridging and whether it is still relevant to treat patients.
- Complement Component C3b and RBCs Provide a Potential Clearance Mechanism for Damaged Plasma ProteinsAugust 12, 2015 | Mark J. Koury, MD
Dr. Koury looks at a study that demonstrates that C3b-mediated erythrocyte clearance of damaged plasma proteins can improve treatment of diseases characterized by tissue accumulation of misfolded or denatured proteins.
- Computed Tomography Provides No Benefit over Routine Screening for Occult CancerAugust 12, 2015 | Tracy I. George, MD
Dr. George evaluates whether there are any advantages to routine screening for occult cancer in using computed tomography (CT).
- Deadly Malaria Parasites Hijack CD55 to Invade Human ErythrocytesAugust 12, 2015 | Theresa Coetzer, PhD
Dr. Coetzer studies how malaria parasites invade human erythrocytes, and the possibility of using hematopoietic stem cell-based forward genetic screening approach to investigate host factors implicated in malaria pathogenesis.
- DUSP4: A New Tumor Suppressor in B-cell Lymphoma With Some Very Druggable TargetsAugust 12, 2015 | Peter Johnson, MD
Dr. Johnson looks at DUSP4 as a new tumor suppressor in B-cell lymphoma.
- Hematopoietic Stem Cells Should Hold Their BreathAugust 12, 2015 | Jonathan Hoggatt, PhD | Hannah K. Rasmussen
Dr. Hoggatt and Hannah Rasmussen discuss new approaches to the use of hematopoietic stem cells considering observer effects that emerge due to our experimental systems for HSCs.
- Shattered Chromosomes: A Cataclysmic Origin of CancerAugust 12, 2015 | Pamela S. Becker, MD, PhD
Dr. Becker discusses an event called chromothripsis, which entails a catastrophic change of genome structure and acquisition of multiple mutations through chromosomal rearrangements, as a cause for cancer.
- Targeted Fetal Hemoglobin Induction Therapy May Need a Blood-Brain BarrierAugust 12, 2015 | Charles T. Quinn, MD, MS
Dr. Quinn talks about safety concerns regarding targeted fetal hemoglobin induction therapy and the role of BCL11A in human neurodevelopment.
- The Evolutionary Trajectory from Diagnosis to Relapse in Pediatric ALLAugust 12, 2015 | Elizabeth Raetz, MD
Dr. Raetz reviews a study that details the trajectory of clonal emergence from diagnosis to relapse in childhood ALL, looking towards earlier detection of genetic lesions that could be a sign of relapse in order to implement alternative therapies before overt disease recurrence.