July-August 2018, Volume 15, Issue 4
Unusual Spindle Cell Lesion Involving Bone Marrow
Published on: July 10, 2018
A 65-year-old man presented with syncope. Imaging showed mild hepatosplenomegaly. No skin lesions were observed. Laboratory evaluation detected pancytopenia with a complete blood count showing the following:
These results prompted a subsequent bone marrow biopsy. Peripheral blood smear showed rare abnormal circulating cells (Figure 1). Bone marrow core biopsy showed clusters of spindle cells adjacent to bony trabeculae (Figure 2) that were positive for CD117 (Figure 3). Scattered teardrop cells were also noted. Molecular testing by next-generation sequencing (NGS) detected diagnostic mutations.