American Society of Hematology

Editors of Blood Select the Top 10 Manuscripts of 2015

Published on: December 17, 2015

(WASHINGTON, December, 17, 2015) – To celebrate the recent achievements in both hematology and in Blood, the Journal of the American Society of Hematology, Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD, have selected the top 10 most outstanding manuscripts of 2015.

“Hematology is at the forefront of a profoundly evolving frontier in medicine in which basic molecular insights are translating into revolutionary treatments for hard-to-treat and incurable diseases,” said Dr. Löwenberg. “As the most-cited journal in hematology, Blood drives this progress. We are pleased to celebrate the importance of Blood to scientific advancement by looking back on the top 10 papers of 2015.”

To identify the following top manuscripts of the year, the editors considered quality of the work, interest to the field of hematology, the number of citations, and how often the paper was accessed.

1) Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib, Byrd et al. DOI: 10.1182/blood-2014-10-606038.

2) International Phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts, Dombret et al. DOI: 10.1182/blood-2015-01-621664.

3) Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells, Hoban et al. DOI: 10.1182/blood-2014-12-615948.

4) The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia, Van der Muelen et al. DOI: 10.1182/blood-2014-05-577270.

5) Early-onset Evans syndrome, immunodeficiency and premature immunosenescence associated with tripeptidyl-peptidase II deficiency, Stepensky et al. DOI: 10.1182/blood-2014-08-593202.

6) Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion, Raghu et al. DOI: 10.1182/blood-2014-08-594754.

7) Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice, Stritt et al. DOI: 10.1182/blood-2014-08-597542.

8) Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations, Milner et al. DOI: 10.1182/blood-2014-09-602763.

9)BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent anti-leukemic activity, Pettirossi et al. DOI: 10.1182/blood-2014-10-603100.

10) Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation, Popat et al. DOI: 10.1182/blood-2015-01-607366.

Blood (, the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online and has been serving the hematology community for 70 years. Blood is the official journal of the American Society of Hematology (ASH) (, the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

blood® is a registered trademark of the American Society of Hematology. Follow Blood on Twitter at @BloodJournal.


Amanda Szabo, American Society of Hematology; 202-552-4914​

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