American Society of Hematology

Barbara Furie, PhD, and Bruce Furie, MD, to Present 2015 American Society of Hematology E. Donnall Thomas Lecture

Published on: July 23, 2015

Bruce and Barbara Furie - E Donnal Thomas

(WASHINGTON, July 23, 2015) The American Society of Hematology (ASH) will honor Barbara Furie, PhD, of Harvard Medical School, and Bruce Furie, MD, of Beth Israel Deaconess Medical Center and Harvard Medical School with the 2015 E. Donnall Thomas Lecture for their groundbreaking research in hemostasis and thrombosis over the last 40 years. Drs. Barbara and Bruce Furie are international leaders in hemostasis and thrombosis and their outstanding research program has made landmark contributions to the understanding of the structure, biochemistry, and function of coagulation and platelet proteins. This award, named after the late Nobel Prize Laureate and past president of ASH E. Donnall Thomas, MD, recognizes pioneering research achievements in hematology that have represented a paradigm shift or significant discovery in the field.

The Furies will present their lecture, “Thiol Isomerases as Potential Regulators Controlling the Initiation of Thrombus Formation,” at 9:00 a.m. on Monday, December 7, at the 57th ASH Annual Meeting and Exposition in Orlando. Their lecture will focus on the use of digital high-speed, multi-channel fluorescence intravital microscopy and its transformative effect on the understanding of the molecular and cellular basis of thrombus formation. They will share insights gleaned from studies in a laser-induced mouse model demonstrating that extracellular thiol isomerases are required for platelet accumulation and fibrin generation during thrombus formation. In addition, they will present data suggesting that the thiol isomerase system may serve as a regulator of thrombus formation prior to vascular injury, in contrast to the regulatory mechanisms that limit thrombus size after vascular injury.

Drs. Barbara and Bruce Furie have been involved in hemostasis and thrombosis research since the early 1970s. In 1975 they founded the Center for Hemostasis and Thrombosis Research at Tufts University School of Medicine and New England Medical Center to conduct interdisciplinary research in the areas of blood coagulation and platelet and vascular biology. During its 40 years in operation, the Furie lab, which moved to Harvard Medical School and the Beth Israel Deaconess Medical Center in 1997 and became the Division of Hemostasis and Thrombosis in 2000, has hosted more than 100 young investigators for research training. The laboratory’s current research focus area is the role of thiol isomerases in thrombus formation.

Dr. Barbara Furie is currently Professor Emeritus at Harvard Medical School, where she previously served as Co-Chief of the Division of Hemostasis and Thrombosis and Professor of Medicine. She earned her PhD in chemistry from the University of Pennsylvania and served in various leadership roles at Tufts University School of Medicine, the New England Medical Center, the Marine Biological Laboratory, and Beth Israel Deaconess Medical Center.

Dr. Bruce Furie is currently Chief of Hemostasis-Thrombosis at Beth Israel Deaconess Medical Center, where he also directs the Blood Coagulation and Vascular Biology Training Program. He also serves as Professor of Medicine at Harvard Medical School. Dr. Furie earned his medical degree from the University of Pennsylvania, where he also completed his internship and residency in medicine. He completed his protein biochemistry training in the Laboratory of Chemical Biology at the National Institutes of Health (NIH) and hematology fellowship at the Upstate Medical Center of the State University of New York in Syracuse. Dr. Furie served in various leadership positions at the New England Medical Center, the Marine Biological Laboratory, and Tufts University School of Medicine prior to joining Beth Israel Deaconess Medical Center and Harvard Medical School.

Their highly productive collaboration has earned the Furies numerous prestigious awards from ASH and other organizations. They received the ASH William Dameshek Prize in 1984 and were each presented with an NIH MERIT Award. In 2008 Dr. Barbara Furie was elected as a Fellow of the American Association for the Advancement of Science. They both served as co-presidents of the 2009 International Society on Thrombosis and Hemostasis Congress. In 2011, Dr. Bruce Furie was selected to deliver the American Heart Association Sherry Distinguished Lectureship and received the International Society of Thrombosis and Hemostasis Distinguished Career Award. In 2014, Dr. Bruce Furie received the Distinguished Scientist Award from the American Heart Association. Dr. Barbara Furie presently serves as Chair of the North American Society on Thrombosis and Hemostasis. Together, the duo has published more than 350 independent peer-reviewed articles and book chapters

“From their work to decipher key steps in carboxylation of vitamin K-dependent coagulation proteins to their discovery of platelet P-selectin, Drs. Barbara and Bruce Furie have uncovered important insights that have placed them at the forefront of research in the field of hemostasis and thrombosis,” said ASH President David A. Williams, MD, of Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School. “I am privileged to honor them with the first-ever joint E. Donnall Thomas Lecture and Prize to celebrate their individual and combined efforts that have improved the understanding and treatment of bleeding and clotting disorders. The Furie laboratory has been a nidus for outstanding research into hemostasis and thrombosis research and I am very pleased that the Awards Committee has selected to recognize their collaborative research efforts for this honor.”

The American Society of Hematology ( is the world’s largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology. The official journal of ASH is Blood (, the most cited peer-reviewed publication in the field, which is available weekly in print and online.

Alicia Davids, American Society of Hematology; 202-552-4925

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