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Training
54. Plasmapheresis and IVIG
Rock GA, Shumak KH, Buskard NA, et al.
Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura.
N Engl J Med. 1991;325:393-7.
Description: Randomized trial of 102 patients demonstrating the benefit of plasmapheresis for treatment of TTP.
PubMed citation number: 2062330
Reimann PM and Mason PD.
Plasmapheresis: technique and complications.
Intensive Care Med. 1990;16:3-10.
Description: Concise review on the principles and different techniques of plasmapheresis.
PubMed citation number: 2179349
Clark WF, Rock GA, Buskard NA, et al.
Therapeutic plasma exchange: an update from the Canadian Apheresis Group.
Ann Intern Med. 1999;131:453-62.
Description: Reviews the five most common usages of plasma exchange in Canada from 1981 to 1997.
PubMed citation number: 10498563
Knezevic-Maramica I and Kruskall MS.
Intravenous immune globulins: an update for clinicians.
Transfusion. 2003;43:1460-80.
Description: Concise clinical review on the usages and adverse effects of IVIG.
PubMed citation number: 14507280
Sewell WAC and Jolles S.
Immunomodulatory action of intravenous immunoglobulin.
Immunology. 2002;107:387-93.
Description: Concise review on the mechanisms of action of IVIG.
PubMed citation number: 12460182
Buckley RH and Schiff RI.
The use of intravenous immune globulin in immunodeficiency diseases.
N Engl J Med. 1991;325:110-7.
PubMed citation number: 2052044
Blanchette V and Carcao M
Intravenous immunoglobulin G and anti-D as therapeutic interventions in immune thrombocytopenic purpura.
Transfus Sci. 1998;19:279-88.
Description: Clinical review on the mechanisms and clinical indications of IVIG and anti-D for ITP.
PubMed citation number: 10351140
Kazatchkine MD and Kaveri SV.
Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin.
N Engl J Med. 2001;345:747-55.
PubMed citation number: 11547745
Yu Z and Lennon VA.
Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases.
N Engl J Med. 1999;340:227-8.
Description: Brief paper that describes the role of the FcRn receptor in IgG modulation.
PubMed citation number: 9895405
Bleeker WK, Teeling JL and Hack CE.
Accelerated auto-antibody clearance by intravenous immunoglobulin therapy. Studies in experimental models to determine the magnitude and time course of the effect.
Blood. 2001;98:3136-42.
PubMed citation number: 11698302
Nydegger UE and Sturzenegger M.
Adverse effects of intravenous immunoglobulin therapy.
Drug Safety. 1999;21:171-85.
Description: Comprehensive review on the different adverse effects associated with IVIG.
PubMed citation number: 10487396
Bussel JB, Kimberly RP, Inman RD et al.
Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura.
Blood. 1983;62:480-6.
Description: One of the first clinical trials using IVIG for ITP.
PubMed citation number: 6191803
Shlomchik, W. D., Couzens, M. S., Tang, C. B., McNiff, J., Robert, M. E., Liu, J., Shlomchik, M. J. and Emerson, S. G.
(1999). "Prevention of graft versus host disease by inactivation of host antigen-presenting cells." Science 285(5426): 412-5. PMID: 10411505.
In a mouse model of allogeneic BMT, only host antigen presenting cells are required for initiation of GVHD.
Solid Tumors and BMT
Curtis, R. E., Rowlings, P. A., Deeg, H. J., Shriner, D. A., Socie, G., Travis, L. B., Horowitz, M. M., Witherspoon, R. P., Hoover, R. N., Sobocinski, K. A., Fraumeni, J. F., Jr. and Boice, J. D., Jr.
(1997). "Solid cancers after bone marrow transplantation." N Engl J Med 336(13): 897-904. PMID: 9070469.
A study of 19,229 allogeneic/syngeneic transplant patients showing an increased risk of development of solid tumors.
Stadtmauer, E. A., O'Neill, A., Goldstein, L. J., Crilley, P. A., Mangan, K. F., Ingle, J. N., Brodsky, I., Martino, S., Lazarus, H. M., Erban, J. K., Sickles, C. and Glick, J. H.
(2000). "Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer". N Engl J Med 342(15): 1069-76. PMID: 10760307.
The study that showed no survival benefit for autoBMT over conventional chemotherapy in metestatic breast cancer.
Non-myeloablative transplant
Khouri, I. F., Keating, M., Korbling, M., Przepiorka, D., Anderlini, P., O'Brien, S., Giralt, S., Ippoliti, C., von Wolff, B., Gajewski, J., Donato, M., Claxton, D., Ueno, N., Andersson, B., Gee, A. and Champlin, R.
(1998). "Transplant-lite: induction of graft-versus malignancy using fludarabine-based nonablative chemotherapy and allogeneic
blood progenitor-cell transplantation as treatment for lymphoid malignancies." J Clin Oncol 16(8): 2817-24. PMID: 9704734.
An early description of non-myeloablative transplant for CLL/lymphoma.

Reviews

Antin, J. H. and J. L. Ferrara.
(1992). "Cytokine dysregulation and acute graft versus-
host disease." Blood 80(12): 2964-8. PMID: 1467511
Champlin, R., Khouri, I., Komblau, S., Molidrem, J. and Giralt, S.
(1999). "Reinventing bone marrow transplantation.
Nonmyeloablative preparative regimens and induction of graft-vs-malignancy effect." Oncology (Huntingt) 13(5): 621-8; discussion 631, 635-8, 641. PMID: 10356683.
Ho, V. T. and R. J. Soiffer.
(2001). "The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation." Blood 98(12): 3192-204. PMID: 11719354.
Korbling, M. and P. Anderlini.
(2001). "Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?" Blood 98(10): 2900-8. PMID: 11698269.
Vogelsang, G.B.
(2001). "How I treat chronic graft-versus-host disease." Blood 97(5): 1196-201. PMID: 11222360.

 

 

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