Landmark pathogenesis

Ludwiczek S, Aigner E, Weiss G.

Cytokine mediated regulation of iron transport in human monocytic cells.
Blood May 15, 2003; 101:4148.
Description: Identifies cytokine mediated regulation of iron transport as a key mechanism in the pathogenesis of anemia of chronic disease.
PubMed citation number: 12522003

Landmark clinical diagnosis

Wians FH Jr, Urban JE, Keffer JH, Kroft SH.

Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs. transferrin receptor concentration.
Am J Clin Pathol January 2001; 115:112.
Description: Evaluates the utility of conventional iron indices to identify anemia of chronic disease. PubMed citation number: 11190796.

Stabler SP, Allen RH, Savage DG, Lindenbaum J.

Clinical spectrum and diagnosis of cobalamin deficiency.
Blood Sept 1, 1990; 76:871-881.
Description: Study demonstrates the importance of methylmalonic acid and total homocysteine in addition to serum B12 and folate levels in diagnosis of B12 and folate deficiency.
PubMed citation number: 2393714

Naurath HJ, Joosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum J.

Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.
Lancet Sept 2, 1995; 346:635.
Description: Demonstrates potential for serum vitamin levels alone to under diagnose vitamin deficiency and the role of methylmalonic acid and total homocysteine in diagnosis.
PubMed citation number: 7603218.

Landmark treatment

Henry DH, Beall GN, Benson CA, Carey J, Cone LA, Eron LJ, Fiala M, Fischl MA, Gabin SJ, Gottlieb MS, et al.

Recombinant human erythropoeitin in the treatment of anemia associated with human inmmunodificiency virus (HIV) infection and zidovudine therapy.
Overview of four clinical trials. Annals of Internal Medicine November 1, 1992; 117:739-48.
Description: Erythropoietin therapy decreases transfusion requirements in HIV patients with anemia of chronic disease and decreased serum erythropoietin levels.
PubMed citation number: 1416576.

Seidenfeld J, Piper M, Flamm C, Hasselblad V, Armitage JO, Bennett CL, Gordon MS, Lichtin AE, Wade JL 3rd, Woolf S, Aronson N.

Epoetin treatment of anemia associated with acner therapy: a systematic review and meta-analysis of controlled clinical trials.
JNCI August 15, 2001; 93:1204-14.
Description: Meta-analysis of controlled trials of erythropoietin in patients with cancer related anemia demonstrates treatment decreases transfusion needs.
PubMed citation number: 11504766.

Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J.

Effective treatment of cobalamin deficiency with oral cobalamin.
Blood August 15, 1998; 92:1191-8.
Description: Randomized trial demonstrates equivalence of oral and IM cobalamin replacement.
PubMed citation number: 9694707.

Review articles

Means RT Jr.

Recent developments in the anemia of chronic disease.
Curr Hematol Rep March 2003; 2:116-21.
PubMed citation number: 12901142.

Toh BH, van Driel IR, Gleeson PA..

Pernicious anemia.
NEJM November 13, 1997; 337:1441-8.
PubMed citation number: 9358143

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