Origin of hematopoiesis

J. Palis and MC. Yoder

Yolk-sac hematopoiesis: the first blood cells of mouse and man
Exp. Hematol. 29: 927-936 (2001)
Description: A current review of embryonic hematopoiesis
PubMed citation number: 11495698

Basic hematopoietic stem cell concepts

I.L. Weissman

Stem cells: units of development, units of regeneration, and units in evolution
Cell 100: 157-168 (2000)
Description: A review of the properties of the stem cells isolated from various somatic tissues, including hematopoietic stem cells
PubMed citation number: 10647940

J.E. Till and E.A. McCulloch

A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
Radiat Res 14: 213-222 (1961)
Description: Till and McCulloch used radiation and engraftment experiments in
mice to directly demonstrate the existence of an ancestral cell that has multilineage potential
PubMed citation number: 13710946

D.E. Harrison, C.T. Jordan, R.K. Zhong, C.M. Astle

Primitive hematopoietic stem cells: direct assay of most productive population by competitive repopulation with simple binomial, correlation and covariance calculations
Exp Hematol 21: 206-219 (1993)
Description: Use of the competitive repopulation assay for quantification of murine hematopoietic repopulating stem cells following transplantation
PubMed citation number: 8425559

C.T. Jordan, I.R. Lemishka

Clonal and systemic analysis of long-term hematopoiesis in the mouse
Genes Dev 4 (2): 220-232 (1990)
Description: Animal reconstitution experiments with hematopoietic cells that were marked genetically with retroviral vectors verified the existence of hematopoietic stem cells and demonstrated their capacity for extensive proliferation, self-renewal and pluripotentiality
PubMed citation number: 1970972

D. Metcalf

Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation
Blood 92 (2): 345-348 (1998)
Description: This review summarizes evidence for and against the deterministic model of stem cell commitment
PubMed citation number: 9657727

T. Enver, C.M. Heyworth, T.M. Dexter

Do stem cells play dice?
Blood 92: 348-351 (1998)
Description: This review summarizes evidence for and against the stochastic model of stem cell commitment
PubMed citation number: 9657728

A.J. Wagner, I.L. Weissman

Plasticity of adult stem cells
Cell 116: 639-648 (2004)
Description: Review of the evidence for and against stem cell plasticity
PubMed citation number: 15006347

Assays for human hematopoietic stem cells

S. Kamel-Reid, J.E. Dick

Engraftment of immune-deficient mice with human hematopoietic stem cells
Science 242: 1706-1709 (1988)
Description: This article reports the first description of human hematopoiesis developing after xenograft of human marrow cells in immune-deficient mice, as an assay of human hematopoietic stem cells
PubMed citation number: 2904703

E.D. Zanjani, M.G. Pallavicini, J.L. Ascensao, A.W. Flake, R.G. Langlois, M. Reitsma, F.R. MacKintosh, D. Stutes, M.R. Harrison, M. Tavassoli

Engraftment and long-term expression of human fetal hematopoietic stem cells in sheep following transplantation in utero
J. Clin Invest 89: 1178-1188 (1992)
Description: This article describes the support of human hematopoiesis after xenograft of human cells in fetal sheep, an alternative assay to immuno-deficient mice for human hematopoietic stem cells.
PubMed citation number: 1348253

Assays for committed hematopoietic progenitor cells

H.J. Sutherland, P.M. Lansdorp, D.H. Henkelman, A.C. Eaves, C.J. Eaves

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilutions on supportive marrow stromal layers
Proc Natl Acad Sci USA 87: 3584-3588 (1990)
Description: This article reports the development of long-term bone marrow culture (LTBMC), an in vitro assay for early-stage hematopoietic progenitors referred to as long-term culture-initiating cells (LTC-ICs)
PubMed citation number: 2333304

G.R. Johnson, D. Metcalf

Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin activity
Proc Natl Acad Sci USA 74: 3879-3882 (1977)
Description: Under culture conditions in semisolid medium with adequate supportive growth factors, progenitors can form colonies of multiple cell lineages in vitro (colony assay)
PubMed citation number: 269439

Hematopoietic microenvironment

M.C. Yoder, D.H. Williams

Matrix molecule interactions with hematopoietic stem cells
Exp. Hematol 23: 961-967 (1995)
Description: Review of the structure and function of the hematopoietic microenvironment
PubMed citation number: 7635183

Hematopoietic growth factors

D. Metcalf

Hematopoietic regulators: redundancy or subtlety?
Blood 82: 3515-3523 (1993)
Description: General review of cytokines in hematopoiesis
PubMed citation number: 8260692

S.B. Krantz

Erythropoietin
Blood 77: 419-434 (1991)
Description: Review on erythropoietin
PubMed citation number: 1991159

D. Metcalf

Control of granulocytes and macrophages: molecular, cellular and clinical aspects
Science 254: 529-533 (1991)
Description: Review on G-CSF and GM-CSF
PubMed citation number: 1948028

D.J. Kuter, C.G. Begley

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
Blood 100: 3457-3469 (2002)
Description: Review on Thrombopoietin
PubMed citation number: 12411315

V.C Broudy

Stem cell factor and hematopoiesis
Blood 90: 1345-1364 (1997)
Description: Review on stem cell factor
PubMed citation number: 9269751

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