Glaser SL and Jarrett RF.

The epidemiology of Hodgkin's disease.
Baillieres Clin Haematol 9(3):401-16 (1996)
Description: This article reviews various epidemiological aspects of Hodgkin’s disease including genetic susceptibility, sex differences, association with social class, EBV and other infectious agents.
PubMed Citation number: 8922237

Kuppers R, Schwering I, Brauninger A, Rajewsky K, Hansmann ML.

Biology of Hodgkin's lymphoma.
Ann Oncol 13 Suppl 1:11-8 (2002)
Description: This paper outlines recent developments related to the origin of the Reed-Sternberg cell in Hodgkin’s disease.
PubMed citation number: 12078890

Pileri SA, Ascani S, Leoncini L, Sabattini E, Zinzani PL, Piccaluga PP, Pileri A Jr, Giunti M, Falini B, Bolis GB, Stein H.

Hodgkin's lymphoma: the pathologist's viewpoint.
J Clin Pathol. 2002 Mar;55(3):162-76
Description: This review article discusses the histopathological classification (REAL/WHO) of Hodgkin’s disease with regard to differences in clinical presentation, morphology, phenotypic and molecular features and differential diagnosis.
PubMed citation number: 11896065

Staging

Lister TA, Crowther D, Sutcliffe SB, Glatstein E, Canellos GP, Young RC, Rosenberg SA, Coltman CA, Tubiana M.

Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting.
J Clin Oncol 7(11):1630-6 (1989)
Description: This report presents an updated staging classification developed from the original Ann Arbor classification for describing the stage of Hodgkin's disease at initial presentation.
PubMed citation number: 2809679

Friedberg JW and Chengazi V.

PET scans in the staging of lymphoma: current status.
Oncologist. 8(5):438-47 (2003)
Description: Positron emission tomography is a novel technique that is increasingly being considered for use in patients with lymphoma. This article summarizes the evidence on the role of PET scans in the staging and follow-up of patients with lymphoma.
PubMed citation number: 14530496

Prognostic factors

Hasenclever D, Diehl V.

A prognostic score for advanced Hodgkin's disease. International Prognostic Factors Project on Advanced Hodgkin's Disease.
N Engl J Med 339(21):1506-14 (1998)
Description: This paper presents a seven-factor prognostic score developed by an international panel based on the evaluation of over 5000 patients with advanced Hodgkin’s disease.
PubMed citation number: 9819449

Schwartz CL.

Prognostic factors in pediatric Hodgkin disease.
Current Oncology Reports 5(6):498-504 ( 2003)
Description: This review article discusses various host factors, tumor burden, clinical features, pathology, biology and response to therapy as prognostic factors in children with Hodgkin’s disease.
PubMed citation number: 14521809

Treatment approaches

Canellos GP. Anderson JR. Propert KJ. Nissen N. Cooper MR. Henderson ES. Green MR. Gottlieb A. Peterson BA.

Chemotherapy of advanced Hodgkin's disease with MOPP, ABVD, or MOPP alternating with ABVD.
N Engl J Med 327(21):1478-84 ( 1992)
Description: This paper reports a randomized trial comparing ABVD, MOPP/ABVD and MOPP in advanced Hodgkin’s disease.
PubMed citation number: 1383821

Aisenberg AC.

Problems in Hodgkin disease management.
Blood 93:761 (1999)
Description: This is a comprehensive review of the management of early and advanced stage, and relapsed disease. The author also reviews various treatment-related toxicities.
PubMed citation number: 9920825

Connors JM, Noordijk EM, Horning S.

Hodgkin lymphoma: basing the treatment on the evidence.
Hematology 2001. ASH Education Program Book: 178–93.
Description: This paper discusses the evidence that led to the development of current treatment approaches in early stage, advanced stage and lymphocyte predominant Hodgkin’s disease.

Moskowitz C.

An update on the management of relapsed and primary refractory Hodgkin's disease.
Seminars in Oncology 31(2 Suppl 4):54-9 ( 2004)
Description: This article reviews current modalities of treatment used in the treatment of relapsed and refractory Hodgkin’s disease, and discusses prognostic factors that affect outcomes after autologous stem cell tansplantation.
PubMed citation number: 15124135

Long-term outcomes

Aleman BM. van den Belt-Dusebout AW. Klokman WJ. Van't Veer MB. Bartelink H. van Leeuwen FE.

Long-term cause-specific mortality of patients treated for Hodgkin's disease.
J Clin Oncol 21(18):3431-9 ( 2003)
Description: This study examines the long-term outcomes of over 1000 patients with a median follow-up of 17 years. Please also read the accompanying editorial commentary on this article in the same issue of the journal by Dr. JM Connors.
PubMed citation number: 12885835

Ng AK and Mauch PM.

Late complications of therapy of Hodgkin's disease: prevention and management.
Current Hematology Reports. 3(1):27-33 (2004)
Description: This article reviews late complications of therapy for Hodgkin’s disease including second malignancies and cardiac disease and outlines the importance of screening programs and preventative therapy in the follow-up care of these patients.
PubMed citation number: 14695846

Bhatia S, Robison LL, Oberlin O, Greenberg M, Bunin G, Fossati-Bellani F, Meadows AT.

Breast cancer and other second neoplasms after childhood Hodgkin's disease.
N Engl J Med 334(12):745-51 ( 1996)
Description: This article reports the risk of second malignancies following treatment for pediatric Hodgkin’s disease. Breast cancer was found to be the most common solid tumor in the study cohort.
PubMed citation number: 8592547

Focus on Pediatrics

Asselin BL, Hudson MM, Mandell L, Constine LS.
Pediatric Leukemias And Lymphomas
in Leibel S, Phillips T (eds): Textbook of Radiation Oncology, 2/e.
Philadelphia: WB Saunders, 2004.
Description: This chapter is a comprehensive review of pediatric leukemias and lymphomas including Hodgkin’s disease. The evolution of therapeutic strategies and the associated adverse events that prompted changes in treatment are explained.

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