Pathogenesis

Ngan BY, Chen-Levy Z, Weiss LM, Warnke RA, Cleary

Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation. ML.
N Engl J Med 318:25 Jun 23, 1988: 1638-1644.
Description: This is one of the first papers that described the association of the bcl-2 proto-oncogene and its expression in virtually all studied follicular lymphomas.

Horning SJ, Rosenberg SA.

The natural history of initially untreated low-grade non-Hodgkin's lymphomas.
N Engl J Med 311:23 Dec 6, 1984: 1471-1475.
Description: This paper reports on the natural history of untreated low-grade NHL including follicular lymphomas and provides an early basis for observation as a treatment.

Treatment

Mac Manus MP, Hoppe RT.

Is radiotherapy curative for stage I and II low-grade follicular lymphoma? Results of a long-term follow-up study of patients treated at Stanford University.
J Clin Oncol 14:4 Apr, 1996: 1282-1290.
Description: This is a retrospective review describing outcomes of patients with stage I and II follicular lymphomas treated with radiation alone.

Czuczman MS, Grillo-Lopez AJ, White CA, Saleh M, Gordon L, LoBuglio AF, Jonas C, Klippenstein D, Dallaire B, Varns C.

Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy.
J Clin Oncol 17:1 Jan, 1999: 268-276.
Description: This is the first report demonstrating the safety and efficacy of rituximab in combination with standard-dose systemic chemotherapy in the treatment of indolent B-cell lymphoma (including follicular lymphoma).

Kaminski MS, Zelenetz AD, Press OW, Saleh M, Leonard J, Fehrenbacher L, Lister TA, Stagg RJ, Tidmarsh GF, Kroll S, Wahl RL, Knox SJ, Vose JM.

Pivotal study of iodine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas.
J Clin Oncol 19:19 Oct 1, 2001: 3918-3928.
Description: This study demonstrates the effectiveness of radioimmunotherapy in patients with chemotherapy-refractory low-grade lymphoma.

McLaughlin P, Grillo-Lopez AJ, Link BK, Levy R, Czuczman MS, Williams ME, Heyman MR, Bence-Bruckler I, White CA, Cabanillas F, Jain V, Ho AD, Lister J, Wey K, Shen D, Dallaire BK.

Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.
J Clin Oncol 16:8 Aug, 1998: 2825-2833.
Description: This study describes the efficacy of a commonly used regimen of single agent rituximab for relapsed indolent lymphoma.

van Besien K, Loberiza FR, Jr., Bajorunaite R, Armitage JO, Bashey A, Burns LJ, Freytes CO, Gibson J, Horowitz MM, Inwards DJ, Marks DI, Martino R, Maziarz RT, Molina A, Pavlovsky S, Pecora AL, Schouten HC, Shea TC, Lazarus HM, Rizzo JD, Vose JM.

Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma.
Blood 102:10 Nov 15, 2003: 3521-3529.
Description: This is a retrospective evaluation comparing the outcomes of patients undergoiong autologous and allogeneic stem cell transplantation for follicular lymphoma revealing similar 5-year overall survival rates. Increased transplant-related mortality was seen with allogeneic transplants with increased recurrences with autologous transplants.

Review

Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, Behm FG

Clinicopathologic analysis of follicular lymphoma occurring in children.
Blood 99:6 Mar 15, 2002: 1959-1964.
Description: This paper describes the clinical and histological features and outcomes of 23 patients with follicular lymphoma carrying this rare pediatric diagnosis.

Hunault-Berger M, Ifrah N, Solal-Celigny P

Intensive therapies in follicular non-Hodgkin lymphomas.
Blood 100:4 Aug 15, 2002: 1141-1152.
Description: This paper reviews studies involving stem cell transplantation in treating follicular lymphomas.

Soubeyran P, Debled M, Tchen N, Richaud P, Monnereau A, Bonichon F, Eghbali H

Follicular lymphomas--a review of treatment modalities.
Crit Rev Oncol Hematol 35:1 Jul, 2000: 13-32.
Description: This is a comprehensive review of a large body of literature on each of the treatment modalities used in caring for patients with follicular lymphoma.

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