Couderc Bernard, Jean-Pierre Dujols, Fatma Mokhtari, Jean-Luc Norkowski, Jean-Claude Slawinski, Daniel Schlaifer.

Management of Adult Aggressive Non-Hodgkin’s Lymphomas.
Critical Reviews in Oncology/Hematology, 35: 33-48, 2000
Description: A good review of treatment options in the various stages of aggressive NHL.
PubMed citation number: 10863150

Tsang R.W., Gospodarowicz M.K.

Management of Localized (Stage I and Stage II) Clinically Aggressive Lymphomas
Annals of Hematology 80(Suppl 3): B66-72, 2001
PubMed citation number: 11757712

Van Besien K, Kelta M, Bahaguna P.

Primary Mediastinal B cell Lymphoma: a Review of Pathology and Management.
Journal of Clinical Oncology 19(6): 1855-64, March 15, 2001.
Description: Review of a distinct subtype of Diffuse Large Cell NHL. This review includes diagnosis, pathology, staging and treatment options.
PubMed citation number: 11251018

Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR

Diffuse Large B Cell Lymphoma outcome prediction by gene expression profiling and supervised machine learning.
Nature Medicine 8(1): 68-74, January 2002
Description: Nice model of correlating clinical courses of diffuse large B cell lymphoma with the various types of gene expression. Not yet standard in clinical practice but helpful in understanding the diversity of DLCL.
PubMed citation number: 11786909

A.A. Alizadeh, Michael B Eisen, R Eric Davis, Chi Ma, Izidore S Lossos, Andreas Rosenwald, Jennifer C Boldrick, Hajeer Sabet, Truc Tran, Xin Yu, John I powell, Limin Yang, Gerald E Marti, Troy Moore, James Hudson Jr, Lisheng Lu, David B Lewis, Robert Tishirani, Gavin Sherlock, Wing C Chan, Timothy C Greiner, Dennis D Weisenburger, James O Armitage, Roger Warnke, Ronald Levy, Wyndham Wilson, Michael R Grever, John C Byrd, David Botstein, Patrick O Brown, Louis M Staudt.

Distinct Types of Diffuse Large B cell Lymphoma identified by gene expression profiling
Nature 2000 403: 503-11
Description: This article complements the previous article on gene expression and clinical outcome in DLCL. This article classifies different types of DLCL based on gene expression and outcomes.
PubMed citation number: 10676951

Coiffier B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah R, Morel P, Van Den Neste E, Salles G, Gaulard P, Reyes F, Lederlin P, Gisselbrecht C

CHOP chemotherapy plus Rituximab compared to CHOP alone in elderly patients with diffuse large B-cell Lymphoma
N Engl J Medicine. 2002 Jan 24; 346(4):235-42
Description: Landmark study that changed standard of care for CD 20 + DLCL.
PubMed citation number: 11807147

Corinne Haioun, Eric Lepage, Christian Gisselbrecht, Gilles Salles, Bertrand Coffier, Pauline Brice, Andre’Bosly, Pierre Morel, Christiane Nouvel, Herve’Tilly, Pierre Lederlin, Catherine Sebban, Josette Briere, Philippe Gaulard, Felix Reyes.

Journal of Clinical Oncology, 2000, 18(16): 3025-3030
Description: This article describes a potential role for transplant for patients with high risk aggressive Non-Hodgkin’s Lymphoma based on IPI score. Data from a randomized trial in poor risk patients definitively address the issue.
PubMed citation number: 10944137

Thierry Philip, Cesare Guglielmi, Anton Hagenbeek, Renier Somers, Hans van der Lelie, Dominique Bron, Pieter Sonneveld, Christian Gisselbrecht, Jean-Ives Chan, Jean-Luc Harousseau, Bertrand Coffier, Pierre Biron, Franco Mandelli, Franck Chauvin

Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive Non-Hodgkins’ Lymphoma.
NEJM 1995, 333(23): 1540-1545
Description: This article describes a role for transplant in patients with aggressive Non-Hodgkin’s lymphoma in first relapse.
PubMed citation number: 7477169

Richard J Fisher, Ellen R Gaynor, Steve Dahlberg, Martin M Oken, Thomas M Grogan, Evonne M Mize, John H Glick, Charles A Coltman Jr, Thomas P Miller

Comparison of Standard Regimen (CHOP) with three intensive chemotherapy regimens for advanced Non-Hodgkin’s Lymphoma
NEJM 1993 328(14): 1002-1006
Description: CHOP chemotherapy is the standard regimen for DLCL NHL. This study is a prospective randomized phase III trial comparing CHOP with three other regimen in NHL. There was no difference in outcomes re-establishing CHOP as the standard of care for the first line treatment of DLCL.
PubMed citation number: 7680764

The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. Shipp et al.

A Predictive Model for Aggressive Non-Hodgkin’s Lymphoma
NEJM 1993 329(14): 987-994
Description: In this article, the IPI score is presented. The IPI score serves the clinician as a diagnostic aide in classifying patients with DLCL as high risk, intermediate risk and low risk. This classification further helps in making treatment plans, such as transplant.
PubMed citation number: 8141877

Thomas P Miller, Steve Dahlberg, J Robert Cassady, David J Adelstein, Catherine M Spier, Thomas M Grogan, Michael LeBlanc, Susan Carlin, Ellen Chase, Richard I Fisher

Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate and high grade Non-Hodkin’s Lymphoma.
NEJM 1998 339(1): 21-26
Description: Establishing a standard of care for early stage DLCL (stage I and II), incorporating fewer doses of chemotherapy and radiation therapy.
PubMed citation number: 9647875

Nancy Lee Harris, Elaine S Jaffe, Jacques Diebold, Georges Flandrin, H Konrad Muller-Hermelink, James Vardiman, T. Andrew Lister, Clara D. Bloomfield.

World Health Organization Classification of Neoplastic Diseases of the Hematopietic and Lymphoid Tissues: Report of the Clinical Advisory Committee Meeting – Airlie House, Virginia, November 1997.
Journal of Clinical Oncology 1999 17(12): 3835-3849
Description: Revised classification, now for a new standard, for pathologists, clinicians, and researchers to communicate.
PubMed citation number: 10577857

Return to Table of Contents