Paraneoplastic Syndromes
Pathophysiology
Neurologic disorders in patients with small cell lung cancer.
Sculier J-P, Feld R, Evans WK, et al.
Cancer 1987;60:2275-2283.
Description: Review of neurologic aspects of PNS, with emphasis on Lambert-Eaton myasthenic syndrome.
PubMed citation number: 2830955
Malignant thymoma associated with autoimmune diseases: a retrospective study and review of the literature.
Levy Y, Afek A, Sherer Y, et al.
Semin Arthritis Rheum. 1998;28:73-79.
Description: Analysis demonstrating the high incidence of PNS associated with thymoma.
PubMed citation number: 9806367
Motor neuron disease and malignancy.
Younger DS.
Muscle Nerve. 2000;23:658-660.
Description: A review that includes discussion of the motor abnormalities in PNS.
PubMed citation number: 10797388
Paraneoplastic syndromes involving the nervous system.
Darnell, RB, Posner, JB.
N Engl J Med. 2003;349:1543-1554.
Description: Recent review of the mechanisms and clinical features of PNS.
PubMed citation number: 14561798
Diagnosis
The role of [(18)F]fluoro-2-deoxyglucose-PET scanning in the diagnosis of paraneoplastic neurological disorders.
Rees, JH, Hain, SF, Johnson, MR, Hughes, RA.
Brain. 2001;124:2223-2231.
Description: Discussion of the potential use of PET scanning in the diagnosis of PNS.
PubMed citation number: 11673324
Treatment
Treatment of paraneoplastic neurological syndromes with antineuronal antibodies (Anti-Hu, anti-Yo) with a combination of immunoglobulins, cyclophosphamide, and methylprednisolone.
Keime-Guibert, F, Graus, F, Fleury, A, et al.
J Neurol Neurosurg Psychiatry. 2000;68:479-482.
Description: Study demonstrating the lack of benefit from immune agents in the management of PNS.
PubMed citation number: 10727484
Review
Paraneoplastic neurologic syndromes: pathogenesis and physiopathology.
Dalmau, J, Gultekin, HS, Posner, JB.
Brain Pathol. 1999;9:275-284.
Description: An overview of the pathophysiology of paraneoplastic syndromes.
PubMed citation number: 10219745
Paraproteinemic neuropathies.
Vital A.
Brain Pathol. 2001;11:399-407.
Description: A review of the neuropathies associated with monoclonal gammopathies.
PubMed citation number: 11556684