Lymphoplasmacytic lymphoma, Waldenstrom’s Macroglobulinemia, and Castleman’s Disease
Lymphoplasmacytic lymphoma/Waldenstrom’s macroglobulinemia
DIAGNOSIS AND PROGNOSIS
Study of prognosis in Waldenstrom's macroglobulinemia: a proposal for a simple binary classification with clinical and investigational utility.
Gobbi PG, Bettini R, Montecucco C, et al.
Blood. 1994;83:2939-2945.
Description: The investigators find that among many variables studied, only hemoglobin, age, weight loss, and cryoglobulinemia independently affected survival in patients with Waldenstrom’s macroglobulinemia.
PubMed citation number: 8180389
Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera, R.
Leuk Lymphoma. 1999;34:25-33.
Description: The t(9;14)(p13;q32) chromosomal translocation is (in some cases) associated with lymphoplasmacytic lymphoma (LPL). It juxtaposes the PAX-5 gene encoding a transcription factor (B-cell specific activator protein [BSAP]) to the Ig heavy-chain gene (IgH) locus.
PubMed citation number: 10350329
TREATMENT
Regression of monoclonal B-cell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy.
Mazzaro C, Franzin F, Tulissi P, et al.
Cancer. 1996;77:2604-2613.
Description: Type II mixed cryoglobulinemia is associated with a high prevalence of bone marrow B-cell lymphomas. IFN-alpha appears to be an effective treatment and can induce regression of the lymphoproliferative disorder.
PubMed citation number: 8640712
Prognostic factors and response to fludarabine therapy in patients with Waldenstrom macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003).
Dhodapkar MV, Jacobson JL, Gertz MA, et al.
Blood. 2001;98:41-48.
Description: The first prospective observational multicenter clinical trial of WM. Treatment was fludarabine; ORR was 36%. The authors also developed a staging system.
PubMed citation number: 11418461
REVIEW
Waldenstrom's macroglobulinemia.
Dimopoulos MA, Alexanian R.
Blood. 1994;83:1452-1459.
PubMed citation number: 8123836
Waldenstrom’s macroglobulinemia: clinical features, complications, and management.
Dimopoulos MA, Panayiotidis P, Moulopoulos LA, Sfikakis P, Dalakas M.
J Clin Oncol. 2000;18:214-226.
PubMed citation number: 10623712
B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including Waldenstrom's macroglobulinemia: a clinical, morphologic, and biologic spectrum of similar disorders.
Pangalis GA, Angelopoulou MK, Vassilakopoulos TP, Siakantaris, MP, Kittas C.
Semin Hematol. 1999;36:104-114.
PubMed citation number: 10319379
Purine nucleoside analogs: emerging roles in indolent lymphoproliferative disorders.
Tallman MS, Hakimian D.
Blood. 1995;86:2463-2474.
PubMed citation number: 7670093
Images in clinical medicine: Waldenstrom's macroglobulinemia.
Wulf G, Pool S.
N Engl J Med. 2001;344:816.
PubMed citation number: 11248158
Castleman’s disease
PATHOGENESIS
Localized mediastinal lymph node hyperplasia resembling thymoma.
Castleman B, Iverson L, Menendez VP.
Cancer. 1956;9:822-830.
Description: The original description of Castleman’s Disease.
PubMed citation number: 13356266
Herpes-like DNA sequences, AIDS-related tumors, and Castleman's disease.
Dupin N, Gorin I, Deleuze J, Agut H, Huraux JM, Escande JP.
N Engl J Med. 1995;333:798.
PubMed citation number: 7643891
Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease.
Belec L, Mohamed AS, Authier FJ, et al.
Blood. 1999;93:3643-3653.
Description: Multicentric Castleman’s disease is associated with the POEMS syndrome. Seven (54%) of 13 POEMS patients had HHV-8 detectable, and the majority was detected in the subset of POEMS patients with MCD.
PubMed citation number: 10339470
TREATMENT
Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy.
Corbellino M, Bestetti G, Scalamogna C, et al.
Blood. 2001;98:3473-3475.
PubMed citation number: 11719390
REVIEW
The management of unicentric and multicentric Castleman's disease: a report of 16 cases and a review of the literature.
Bowne WB, Lewis JJ, Filippa DA, et al.
Cancer. 1999;85:706-717.
PubMed citation number: 10091744
Images in clinical medicine: Castleman's disease.
Sickel JZ.
N Engl J Med. 1995;333:776.
PubMed citation number: 7643885