B-cell Lymphoblastic Leukemia/Lymphoma
Pathophysiology
Late-effects among survivors of leukaemia and lymphoma during childhood and adolescence.
Robison LL, Bhatia S.
Br J Haematol. 2003;122:345-359.
Description: Review of late adverse outcomes in patients treated for leukemia and lymphoma as children, specifically secondary malignancy, cardiac, endocrine, neurocognitive effects, and late mortality, to design follow-up guidelines and prevention measures.
PubMed citation number: 12877662
Acute lymphoblastic leukaemia in adults: immunological subtypes and clinical features at presentation.
van't Veer MB, van Putten WL, Verdonck LF, et al.
Ann Hematol. 1993;66:277-282.
Description: Immunologic analysis of leukemic blasts in adult patients with ALL to compare features of clinical symptoms, physical examination, and routine laboratory tests at diagnosis between disease types (B-cell, T-cell, biphenotypic).
PubMed citation number: 7686403
Cytokine/cytokine receptor gene expression in childhood acute lymphoblastic leukemia: correlation of expression and clinical outcome at first disease recurrence.
Wu S, Gessner R, von Stackelberg A, Kirchner R, Henze G, Seeger K.
Cancer. 2005;103:1054-1063.
Description: Evaluation of the relationship between cytokine and cytokine receptor expression in leukemia cells, clinical features, and outcome in pediatric patients with ALL.
PubMed citation number: 15651075
Diagnosis
Molecular diagnostics on lymphoid malignancies.
Chan WC, Fu K.
Arch Pathol Lab Med. 2004;128:1379-1384.
Description: Overview of recent improvements in molecular techniques as related to lymphoid malignancies and initial diagnosis, disease monitoring, and providing prognostic information.
PubMed citation number: 15578882
Molecular analysis of minimal residual disease in adult acute lymphoblastic leukemia.
Foroni L, Hoffbrand AV.
Best Pract Res Clin Haematol. 2002;15:71-90.
Description: Adult ALL study evaluating minimal residual disease in bone marrow specimens using immunoglobulin gene markers revealed MRD-positive patients had increased relapse rates and is an important consideration in treatment plan.
PubMed citation number: 11987917
Long-term results of treatment studies for childhood acute lymphoblastic leukemia: Pediatric Oncology Group studies from 1986-1994.
Maloney KW, Shuster JJ, Murphy S, Pullen J, Camitta BA.
Leukemia. 2000;14:2276-2285.
Description: Pediatric Oncology Group 5- and 10-year EFS study results of pediatric patients with ALL and evaluation of risk criteria which demonstrated in patients with B-cell disease favorable prognostic indicators, including a DNA index greater than 1.16 and trisomy 4 and 10.
PubMed citation number: 11187919
Lack of benefit of early detection of relapse after completion of therapy for acute lymphoblastic leukemia.
Rubnitz JE, Hijiya N, Zhou Y, Hancock ML, Rivera GK, Pui CH.
Pediatr Blood Cancer. 2005;44:138-141.
Description: Retrospective review of pediatric patients with relapsed ALL comparing rates of second remission and subsequent survival in 3 groups based on presence of symptoms and time of evaluation, which revealed no statistically significant difference in outcome between these groups and no benefit to early diagnosis by blood work prior to symptom development.
PubMed citation number: 15390274
Treatment
Combined therapy in the treatment of primary mediastinal B-cell lymphoma: conventional versus escalated chemotherapy.
Aviles A, Garcia EL, Fernandez R, Gonzalez JL, Neri N, Diaz-Maqueo JC.
Ann Hematol. 2002;81:368-373.
Description: Controlled clinical trial comparing conventional chemotherapy to intensive chemotherapy with mantle external beam radiation in patients with mediastinal B-cell lymphoma; did not demonstrate statistically significant different complete disease response rate, but combination therapy had higher failure-free and overall survival rates at 5 years.
PubMed citation number: 12185505
CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trials.
Clarke M, Gaynon P, Hann I, et al.
J Clin Oncol. 2003;21:1798-1809.
Description: Meta-analysis of randomized clinical trials to evaluate the effect on relapse and survival of different treatment regimens directed at CNS disease in childhood ALL determined radiation and long-term intrathecal methotrexate were not statistically different, but that intravenous methotrexate did improve EFS.
PubMed citation number: 12721257
Therapy of non-Hodgkin's lymphoma.
Coffey J, Hodgson DC, Gospodarowicz MK.
Eur J Nucl Med Mol Imaging. 2003;30:S28-S36.
Description: Review of treatment for both follicular lymphoma stages I-IV as model of indolent disease and diffuse large B-cell lymphoma as aggressive lymphoma.
PubMed citation number: N/A
Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995.
Gaynon PS, Trigg ME, Heerema NA, et al.
Leukemia. 2000;14:2223-2233.
Description: Discussion of improved EFS and CNS disease relapse rate between 2 Children’s Cancer Group study series with different treatment protocols, specifically the importance of delayed intensification, single or double depending on risk group, augmented regimen for slow responders, and addition of radiation and dexamethesone in place of prednisone.
PubMed citation number: 11187913
A systematic overview of chemotherapy effects in B-cell chronic lymphocytic leukaemia.
Kimby E, Brandt L, Nygren P, Glimelius B.
Acta Oncol. 2001;40:224-230.
Description: Results presented from 20 randomized, controlled trials and 1 meta-analysis summarizing specific chemotherapeutic agents or treatment protocols and patient outcome data.
PubMed citation number: 11441934
The role of allogeneic transplantation in non-Hodgkin's lymphoma.
Peggs KS, Mackinnon S, Linch DC.
Br J Haematol. 2005;128:153-168.
Description: Discussion of the role of stem cell transplantation in patients with non-Hodgkin lymphoma, particularly those with histologic types associated with poor prognosis and those with poor cure rates.
PubMed citation number: 15638849
In vitro drug resistance profiles of adult versus childhood acute lymphoblastic leukaemia.
Styczynski J, Pieters R, Huismans DR, Schuurhuis GJ, Wysocki M, Veerman AJ.
Br J Haematol. 2000;110:813-818.
Description: Study comparing in vitro drug resistance of adult ALL patients to children with ALL by MTT assay demonstrated higher resistance to ARA-C, asparaginase, daunorubicin, dexamethasone, and prednisone in adult lymphoblasts, which may explain differences in outcome.
PubMed citation number: 11054062
Review
Adult Burkitt leukemia and lymphoma.
Blum KA, Lozanski G, Byrd JC.
Blood. 2004;104:3009-3020.
Description: Comprehensive review of adult Burkitt leukemia and lymphoma, including clinical presentation, immunophenotyping, genetic features, pathogenesis, prognostic features, current treatment protocols with outcome data, and future directions for therapy.
PubMed citation number: 15265787