Red Cell Aplasia and Hypoplasia

Red Cell Aplasia

CONGENITAL

Hypoplastic anemia.

Diamond LK, Blackfan KD
Am J Dis Child. 1938;56:464.
Description: Diamond Blackfan anemia (DBA) was first recognized as a discrete entity in 1938 as a rare aregenerative anemia of childhood.
PubMed citation number: N/A

Inherited bone marrow failure syndrome.

Alter BP.
In: Nathan DG, Orkin SH, Look AT, Ginsburg D, eds. Nathan and Oski’s Hematology of Infancy and Childhood, 6th ed. Philadelphia, PA: WB Saunders; 2003:280-365.
Description: Up-to-date review of Diamond-Blackfan anemia.
PubMed citation number: N/A

ACQUIRED

Transient erythroblastopenia of childhood: prospective study of fifty patients.

Cherrick I, Karayalcin G, Lanzkowsky P.
Am J Pediatr Hematol Oncol. 1994;16:320.
Description: Transient erythroblastopenia of childhood (TEC) is a form of acquired red cell aplasia. This article reports laboratory findings in TEC and a lack of physical abnormalities in patients with TEC.
PubMed citation number: 7978049

The bone marrow failure syndromes.

Alter BP, Young NS.
In: Nathan DG, Orkin SH, Look AT, Ginsburg D, eds. Nathan and Oski’s Hematology of Infancy and Childhood, 6th ed. Philadelphia, PA: WB Saunders; 2003.
Description: Classic book providing an extensive review of pathogenesis, etiology, diagnosis, and treatment of both congenital and acquired red cell aplasia.
PubMed citation number: N/A

Red Cell Hypoplasia

ANEMIA OF RENAL DISEASE

Correction of the anemia of end-stage renal disease with recombinant human erythropoietin: results of a combined phase I and II clinical trial.

Escgbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW.
N Engl J Med. 1987;316:73-78.
Description: First paper documenting efficacy of recombinant erythropoietin to treat anemia in patients with renal failure.
PubMed citation number: 3537801

N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2.

Tarumoto T, Imagawa S, Ohmine K, et al.
Blood. 2000;96:1716-1722.
Description: Paper showing the molecular basis for erythropoietin suppression in patients with end-stage kidney disease .
PubMed citation number: 10961869

National Kidney Foundation: dialysis outcome quality initiative: development of methodology for clinical practice guidelines.

Levin N, Eknoyan G, Pipp M, Steinberg E.
Nephrol Dial Transplant. 1997;12:2060-2063.
Description: Clinical practice guidelines for dialysis patients, including the recommended dosages of erythropoietin for patients with kidney disease.
PubMed citation number: 9351065

ANEMIA OF ENDOCRINE DISORDERS

Thyroid hormones stimulate erythropoiesis in vitro.

Golde DW, Bersch N, Chopra IJ, Cline MJ.
Br J Haematol. 1977;37:173-177.
Description: Paper describing the role of thyroid hormone function on erythropoiesis.
PubMed citation number: 603753

Anemia and secondary hyperparathyroidism.

Zingraff T, Drueke P, Marie NK, Man P, Jungers P, Bordier J.
Arch Intern Med. 1978;138:1650-1652.
Description: Paper describing the role of parathyroid hormone as an inhibitor of erythropoiesis .
PubMed citation number: 718313

ANEMIA SECONDARY TO MALNUTRITION AND STARVATION

Hematologic changes in anorexia nervosa.

Amrein P, Friedman R, Kosinski K, Ellman L.
JAMA. 1979;241:2190-2191.
Description: Review of hematologic changes in patients with a severe eating disorder.
PubMed citation number: 219270

IRON DEFICIENCY ANEMIA

Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status versus transferrin receptor concentration.

Wians FH, Urban JE, Keffer JH, Kroft SH.
Am J Clin Pathol. 2001;115:112-118.
Description: Review of interpretation of indices of iron status and transferrin receptor concentration in the diagnosis of iron deficiency anemia and anemia of chronic disease.
PubMed citation number: 11190796

The rationale for treating iron deficiency anemia.

Crosby W.
Arch Intern Med. 1984;144:471-472.
Description: Review of treatment of iron deficiency anemia.
PubMed citation number: 6703813

ANEMIA SECONDARY TO MARROW INFILTRATION

Erythropoietin for the treatment of anemia of malignancy associated with neoplastic bone marrow infiltration.

Oster W, Herrmann F, Gamm H, Zeile G, Lindemann A, Muller G, Brune T, Kraemer HP, Mertelsmann R.
J Clin Oncol. 1990;8:956-962.
Description: Description of the use of erythropoietin to treat anemia of bone marrow infiltration.
PubMed citation number: 2189957

Other causes of hypoplastic anemia are discussed in separate sections.