Nutritional Deficiencies and Anemia of Chronic Disease
Diagnosis
Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs. transferring receptor concentration.
Wians FH Jr, Urban JE, Keffer JH, Kroft SH.
Am J Clin Pathol. 2001;115:112-118.
Description: Evaluates the utility of conventional iron indices to identify anemia of chronic disease.
PubMed citation number : 11190796
Clinical spectrum and diagnosis of cobalamin deficiency.
Stabler SP, Allen RH, Savage DG, Lindenbaum J.
Blood. 1990;76:871-881.
Description: Study demonstrates the importance of methylmalonic acid and total homocysteine in addition to serum B12 and folate levels in diagnosis of B12 and folate deficiency.
PubMed citation number : 23993714
Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.
Naurath HG, Joosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum J.
Lancet. 1995;346:85-89.
Description: Demonstrates potential for serum vitamin levels alone to under diagnose vitamin deficiency and the role of methylmalonic acid and total homocysteine in diagnosis.
PubMed citation number : 7603218
Pathophysiology
Cytokine-mediated regulation of iron transport in human monocytic cells.
Ludwiczek S, Aigner E, Weiss G.
Blood. 2003;101:4148-4154.
Description: Identifies cytokine-mediated regulation of iron transport as a key mechanism in the pathogenesis of anemia of chronic disease.
PubMedcitation number: 12522003
Prevalence of anemia in persons greater than 65 and older in the United States: evidence for a high rate of unexplained anemia.
Guralnik J, Eisenstaedt R, Ferrucci L, Klein H, Woodman R.
Blood. 2004;104:2263-2268.
Description: Survey of patients identified through the Third National Health and Nutrition examination survey to determine age- and sex-specific prevalence rates of anemia as well as their underlying causes.
PubMed citation number : 15238427
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.
Ganz T.
Blood. 2003;102:783-788.
Description: Review of the role of hepcidin in anemia and iron metabolism.
PubMed citation number : 12663437
Treatment
Recombinant human erythropoietin in the treatment of anemia associated with human immunodeficiency (HIV) infection and zidovudine therapy.
Henry DH, Bealll GN, Benson CA, et al.
Ann Int Med. 1992;117:739-748.
Description: Overview of 4 clinical trials using erythropoietin to decrease transfusion requirements in HIV patients with anemia of chronic disease and decreased serum erythropoietin levels.
PubMed citation number: 1416576
Erythropoetin treatment of anemia associated with cancer therapy: a systematic review and meta-analysis of controlled clinical trials.
Seidenfeld J, Piper M, Flamm C, et al.
J Natl Cancer Inst. 2001;93:1204-1214.
Description: Meta-analysis of controlled trials of erythropoietin in patients with cancer-related anemia demonstrates treatment decreases transfusion needs.
PubMed citation number : 11504766
Effective treatment of cobalamin deficiency with oral cobalamin.
Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J.
Blood. 1998;92:1191-1198.
Description: Randomized trial demonstrates equivalence of oral and IM cobalamin replacement.
PubMed citation number : 9694707
Erythropoetin therapy.
Goodnough L, Monk T, Andriole G.
N Eng J Med. 1997;336:933-938.
Description: Review of the use of erythropoietin in the perioperative period.
PubMed citation number : 9070475
Review
Medical progress: anemia of chronic disease.
Weiss G, Goodnough L.
N Eng J Med. 2005;352:1011-1023.
Description: Review of pathogenesis, diagnosis, and treatment of anemia of chronic disease.
PubMed citation number: 15758012
Recent developments in the anemia of chronic disease.
Means RT Jr.
Curr Hematol Rep. 2003;2:116-121.
Description: Review of anemia of chronic disease.
PubMed citation number: 12901142
Pernicious anemia.
Toh BH, van Driel IR, Gleeson PA.
N Eng J Med. 1997;337:1441-1448.
Description: Review of pernicious anemia.
PubMed citation number : 9358143