Disseminated Intravascular Coagulation
Pathophysiology
Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.
Levi M, Dorffler-Melly J, Reitsma P, Buller H, Florquin S, van der Poll T, Carmeliet P.
Blood. 2003;101:4823-4827.
Description: Molecular aspects of DIC.
PubMed citation number: 12609841
Advances in the understanding of pathogenetic pathways of disseminated intravascular coagulation result in more insight in the clinical picture and better management strategies.
Levi M, de Jonge E, van der Poll T, ten Cate H.
Semin Thromb Hemost. 2001;27:569-575.
Description: Review of pathogenesis with possible clinical applications.
PubMed citation number: 11740680
Diagnosis
Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases.
Siegal T, Seligsohn U, Aghai E, Modan M.
Thromb Haemost. 1978;39:122.
Description: Historical diagnosis of DIC.
PubMed citation number: 580488
Screening tests of disseminated intravascular coagulation: guidelines for rapid and specific laboratory diagnosis.
Yu M, Nardella A, Pechet L.
Crit Care Med. 2000;28:1777-1780.
Description: Diagnostic criteria for DIC.
PubMed citation number: 10890618
Diagnosis of disseminated intravascular coagulation: role of D-dimer.
Carr JM, McKinney M, McDonagh J.
Am J Clin Pathol. 1989;91:280-287.
Description: Use of D-dimer in the diagnosis of DIC.
PubMed citation number: 2646905
Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compare patterns of antithrombin III, protein C, and protein S deficiencies.
Fourrier F, Chopin C, Goudemand J, et al.
Chest .1992;101:816-823.
Description: Comparison in lab findings in different etiologies of DIC.
PubMed citation number: 1531791
Treatment
Treatment of disseminated intravascular coagulation.
Feinstein, DI.
Semin Thromb Haem. 1998;14:351-362.
Description: Review of the treatment of DIC.
PubMed citation number: 3057632
Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis.
Gando S, Nanzaki S, Kemmotsu O.
Ann Surg. 1999;229:121-127.
Description: Clinical decision-making in DIC after trauma.
PubMed citation number: 9923809
Efficacy and safety of recombinant human activated protein C for severe sepsis.
Bernard GR, Vincent JL, Laterre PF, et al.
N Engl J Med. 2001;344:699-709.
Description: Use of activated protein C in severe sepsis.
PubMed citation number: 11236773
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial.
Warren BL, Eid A, Singer P, et al.
JAMA. 2001;286:1869-1878.
Description: A negative trial of the therapeutic use of antithrombin III in patients with severe sepsis.
PubMed citation number: 11597289
Review
Disseminated intravascular coagulation.
Levi M, Cate HT.
N Engl J Med. 1999;341:586-592.
Description: Review of pathogenesis, diagnosis, and management of DIC.
PubMed citation number: 10451465
Disseminated intravascular coagulation: old disease, new hope.
Toh CH, Dennis M.
BMJ. 2003;327:4823-4827.
Description: Review article of DIC.
PubMed citation number: 14576251