Antiphospholipid Antibody Syndrome
Diagnosis
Clinical laboratory testing for the antiphospholipid antibody syndrome.
Pierangeli SS, Harris EN.
Clin Chim Acta. 2005;May 10 [Epub ahead of print].
Description: This paper discusses recent advances in laboratory testing for the antiphospholipid antibody syndrome, including the recent emergence and utility of anti-beta(2)GPI testing.
PubMed citation number: 15893301
Validation of the preliminary criteria for the classification of catastrophic antiphospholipid antibody syndrome
Cervera R, Font J, Gomez-Puerta JA, et al.
Ann Rheum Dis. 2005;Feb 11 [Epub ahead of print].
Description: This paper reviews a cohort of patients with catastrophic antiphospholipid antibody syndrome, and describes clinical characteristics, response to various therapies, and validation of preliminary diagnostic criteria for this syndrome.
PubMed citation number: 15708888
Antiphospholipid syndrome: clinical and diagnostic utility of laboratory tests
Galli M, Barbui T.
Semin Thromb Hemost. 2005;31:17-24.
Description: A systematic review of recently published articles, assessing various laboratory tests for antiphospholipid antibody syndrome, and the respective risk of clinical thrombosis associated with each. PubMed citation number: 15706471
Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients.
Cervera R, Piette JC, Font J, et al.
Arthritis Rheum. 2002;46:1019-1027.
Description: A large descriptive study correlating the broad spectrum of manifestations of APS to sex, age of onset, and associations with SLE.
PubMed citation number: 11953980
Pathophysiology
Genetics of antiphospholipid syndrome.
Horita T, Merrill JT.
Curr Rheumatol Rep. 2004;6:458-462.
Description: A concise review of various genetic factors associated with susceptibility to antiphospholipid antibody syndrome, including human leukocyte antigen associations.
PubMed citation number: 15527705
Molecular pathogenesis of the antiphospholipid antibody syndrome.
Rand JH.
Circ Res. 2002;90:29-37.
Description: An in-depth look at some of the major mechanisms implicated in the pathogenesis of antiphospholipid antibody syndrome, with an emphasis on the high affinity of anti-beta(2)GPI complex for phospholipids membranes.
PubMed citation number: 11786515
Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with antiphospholipid antibody syndrome.
Rand JH, Wu XX, Lapinski R, et al.
Blood. 2004;104:2783-2790.
Description: This study identifies “annexin A5 resistance” with resultant interference with anticoagulant activity, as a novel mechanism of thrombosis in patients with antiphospholipid antibody syndrome.
PubMed citation number: 15242878
Treatment
A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome.
Crowther MA, Ginsberg JS, Julian J, et al.
N Engl J Med. 2003;349:1133-1138.
Description: This prospective randomized comparison of low- and high-intensity warfarin concludes that moderate-intensity warfarin (INR 2-3) is appropriate for patients with the antiphospholipid antibody syndrome. Previously, a retrospective study (N Engl J Med. 1995:332:993-997; PMID 7885428) had suggested the superiority of high intensity (INR >3) over low-intensity warfarin or aspirin.
PubMed citation number: 13679527
A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS).
G. Finazzi G, R. Marchioli R, V. Brancaccio V, et al.
J Thromb Haemost. 2005;3:848-853.
Description: A randomized, prospective trial confirming the lack of superiority of high-intensity warfarin, compared with standard-dose treatment in patients with antiphospholipid antibody syndrome.
PubMed citation number: 15869575
Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies.
Triolo G, Ferrante A, Ciccia F, et al.
Arthritis Rheum. 2003;48:728-731.
Description: First randomized study establishing the superiority of LMW heparin plus low-dose aspirin versus IVIG in pregant patients with known antiphospholipid antibody syndrome.
PubMed citation number: 12632426
Treatment of the antiphospholipid antibody syndrome.
Wu C, Kalunian K.
Curr Rheumatol Rep. 2004;6:463-468.
Description: An overview of recent randomized, controlled trials in antiphospholipid antibody syndrome, suggesting different treatment algorithms should be followed based on different clinical manifestations.
PubMed citation number: 15527706
Review
The antiphospholipid antibody syndrome.
Rand JH.
Annu Rev Med. 2003;54:409-424.
Description: A timely review of recent advances in the pathogenesis, diagnosis, and therapy of antiphospholipid antibody syndrome.
PubMed citation number: 12414917
Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations.
Avcin T, Cimaz R, Meroni PL.
Lupus. 2002;11:4-10.
Description: This review summarizes the recent data on the prevalence and clinical significance of antiphospholipid syndrome in neonates, children, and adolescents.
PubMed citation number: 1189891
Update on the management of the pregnant patient with antiphospholipid antibody.
Sammaritano LR.
Curr Rheumatol Rep. 2001;3:213-321.
Description: Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials.
PubMed citation number: 11352790