Hypercoagulable States
Pathophysiology
Genetic testing for thrombophilia mutations.
Hertzberg MS.
Semin Thromb Hemost. 2005;31:33-38.
Description: This paper summarizes recent advances in genetic testing for thrombophilia mutations, including various emerging DNA methodologies.
PubMed citation number: 15706473
Elevated clotting factor levels and venous thrombosis.
Bertina RM.
Pathophysiol Haemost Thromb. 2004;33:395-400.
Description: Discussion of the recently recognized association between elevated clotting factor levels and risk for venous thromboembolism, including the molecular basis of these plasma phenotypes.
PubMed citation number: 15692250
Treatment
Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancer.
Couban S, Goodyear M, Burnell M, et al.
J Clin Oncol. 2005;Mar 14 [Epub ahead of print].
Description: Randomized prospective study suggesting that prophylactic low-dose warfarin (1 mg daily) does not reduce the incidence of symptomatic CVC-associated thrombosis in patients with cancer.
PubMed citation number: 15767639
Enoxaparin for the prevention of venous thromboembolism associated with central vein catheter: a double-blind, placebo-controlled, randomized study in cancer patients.
Verso M, Agnelli G, Bertoglio S, et al.
J Clin Oncol. 2005;23:4057-4062.
Description: Key randomized trial demonstrating no benefit for prophylactic-dose Enoxaparin in prevention of CVC-related VTE.
PubMed citation number: 15767643
The randomized comparison of low-molecular-weight heparin versus oral anticoagulant therapy for the prevention of recurrent venous thromboembolism in patients with cancer (CLOT) investigators.
Lee AYY, Levine MN, Baker RI, et al.
N Engl J Med. 2003;349:146-153.
Description: Randomized study demonstrating superiority of LMWH dalteparin, compared with coumadin, in reducing risk of recurrent thromboembolism, without increased bleeding risk.
PubMed citation number: 12853587
Review
Management options for thrombophilias.
Gallus AS.
Semin Thromb Hemost. 2005;31:118-126.
Description: Update on key management issues in thrombophilias, including treatment intensity, treatment duration, and family screening.
PubMed citation number: 15706484
Venous thromboembolism and cancer: new issues for an old topic.
Mandala M, Ferretti G, Cremonesi M, Cazzaniga M, Curigliano G, Barni S.
Crit Rev Oncol Hematol. 2003;48:65-80.
Description: A thorough review of the epidemiology, pathophysiology, risk factors, and therapy of venous thromboembolism associated with underlying malignancy.
PubMed citation number: 14585484