Normal Hematopoiesis
Origin of Hematopoiesis
Yolk-sac hematopoiesis: the first blood cells of mouse and man.
Palis J, Yoder MC.
Exp Hematol. 2001;29:927-936.
Description: A current review of embryonic hematopoiesis.
PubMed citation number: 11495698
Basic Hematopoietic Stem Cell Concepts
Stem cells: units of development, units of regeneration, and units in evolution.
Weissman IL.
Cell. 2000;100:157-168.
Description: A review of the properties of the stem cells isolated from various somatic tissues, including hematopoietic stem cells.
PubMed citation number: 10647940
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.
Till JE, McCulloch EA.
Radiat Res. 1961;14:213-222.
Description: Till and McCulloch used radiation and engraftment experiments in mice to directly demonstrate the existence of an ancestral cell that has multilineage potential.
PubMed citation number: 13710946
Primitive hematopoietic stem cells: direct assay of most productive population by competitive repopulation with simple binomial, correlation and covariance calculations.
Harrison DE, Jordan CT, Zhong RK, Astle CM.
Exp Hematol. 1993;21:206-219.
Description: Use of the competitive repopulation assay for quantification of murine hematopoietic repopulating stem cells following transplantation.
PubMed citation number: 8425559
Clonal and systemic analysis of long-term hematopoiesis in the mouse.
Jordan CT, Lemishka IR.
Genes Dev. 1990;4:220-232.
Description: Animal reconstitution experiments with hematopoietic cells that were marked genetically with retroviral vectors verified the existence of hematopoietic stem cells and demonstrated their capacity for extensive proliferation, self-renewal, and pluripotentiality.
PubMed citation number: 1970972
Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation.
Metcalf D.
Blood. 1998;92:345-348.
Description: This review summarizes evidence for and against the deterministic model of stem cell commitment.
PubMed citation number: 9657727
Evidence that hematopoiesis may be a stochastic process in vivo.
Abkowitz JL, Catlin SN, Guttorp P.
Nature Med. 1996;2:190-197.
Description: This innovative mathematical study of hematopoiesis provides evidence for the stochastic model of stem cell commitment.
PubMed citation number: 8574964
Plasticity of adult stem cells.
Wagner AJ, Weissman IL.
Cell. 2004;116:639-648.
Description: Review of the evidence for and against stem cell plasticity.
PubMed citation number: 15006347
Assays for Human Hematopoietic Stem Cells
Engraftment of immune-deficient mice with human hematopoietic stem cells.
Kamel-Reid S, Dick JE.
Science. 1988;242:1706-1709.
Description: This article reports the first description of human hematopoiesis developing after the xenograft of human marrow cells in immune-deficient mice, as an assay of human hematopoietic stem cells.
PubMed citation number: 2904703
Engraftment and long-term expression of human fetal hematopoietic stem cells in sheep following transplantation in utero.
Zanjani ED, Pallavicini MG, Ascensao JL, et al.
J Clin Invest. 1992;89:1178-1188.
Description: This article describes the support of human hematopoiesis after the xenograft of human cells in fetal sheep, an alternative assay to immunodeficient mice for human hematopoietic stem cells.
PubMed citation number: 1348253
Assays for Committed Hematopoietic Progenitor Cells
Functional characterization of individual human hematopoietic stem cells cultured at limiting dilutions on supportive marrow stromal layers.
Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ .
Proc Natl Acad Sci U S A. 1990;87:3584-3588.
Description: This article reports the development of long-term bone marrow culture (LTBMC), an in vitro assay for early-stage hematopoietic progenitors referred to as long-term culture-initiating cells (LTC-ICs).
PubMed citation number: 2333304
Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin activity.
Johnson GR, Metcalf D.
Proc Natl Acad Sci U S A. 1977;74:3879-3882.
Description: Under culture conditions in semisolid medium with adequate supportive growth factors, progenitors can form colonies of multiple cell lineages in vitro (colony assay).
PubMed citation number: 269439
Hematopoietic Microenvironment
Matrix molecule interactions with hematopoietic stem cells.Yoder MC, Williams DH.
Exp Hematol. 1995;23:961-967.
Description: Review of the structure and function of the hematopoietic microenvironment.
PubMed citation number: 7635183
Hematopoietic Growth Factors
Hematopoietic regulators: redundancy or subtlety?
Metcalf D.
Blood. 1993;82:3515-3523.
Description: General review of cytokines in hematopoiesis.
PubMed citation number: 8260692
Erythropoietin.
Krantz SB.
Blood. 1991;77:419-434.
Description: Review of erythropoietin.
PubMed citation number: 1991159
Control of granulocytes and macrophages: molecular, cellular and clinical aspects.
Metcalf D.
Science. 1991;254:529-533.
Description: Review of G-CSF and GM-CSF.
PubMed citation number: 1948028
Recombinant human thrombopoietin: basic biology and evaluation of clinical studies.
Kuter DJ, Begley CG.
Blood. 2002;100:3457-3469.
Description: Review of thrombopoietin.
PubMed citation number: 12411315
Stem cell factor and hematopoiesis.
Broudy VC.
Blood. 1997;90:1345-1364.
Description: Review of stem cell factor.
PubMed citation number: 9269751