Acquired Non-immune Hemolytic Anemias
Diagnosis
Red blood cell enzymes and their clinical application.
Fujii H, Miwa S.
Adv Clin Chem. 1999;33:1-54.
Description: Review of enzymopathies leading to hemolysis and various methods for diagnosis.
PubMed citation number: 10086174
Pathophysiology
Paroxysmal nocturnal hemoglobinuria as a molecular disease.
Rosse WF.
Rev in Mol Med. 1997;76:63-93.
Description: Review of the pathogenesis of PNH
PubMed citation number: 9100736
Natural history of paroxysmal nocturnal hemoglobinuria.
Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV.
N Eng J Med. 1995;333:1253-1258.
Description: Retrospective review of 80 patients with PNH, assessing overall survival, rate of thrombosis, rate of leukemia, and cause of death.
PubMed citation number: 75660002
Mechanisms of hemolysis in liver disease.
Morse EE.
Ann of Clin & Lab Science. 1990;20:169-174.
Description: Discussion of the mechanisms of megaloblastic changes and hemolysis in patients with liver disease and cirrhosis.
PubMed citation number: 2188563
The role of the spleen in hemolysis.
Ferrant A.
Clin in Haem. 1983;12:489-504.
Description: Review of the pathogenesis of hemolysis, with a focus on the contribution of the spleen.
PubMed citation number: 6352113
Hemolysis and infection: categories and mechanisms of their interrelationship.
Berkowitz FE.
Reviews of Infectious Diseases. 1991;13:1151-1162.
Description: In-depth review of the etiology of red blood cell hemolysis secondary to infectious processes.
PubMed citation number: 1775848
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causes nonspherocytic hemolytic anemia.
Wang C, Chiarelli LR, Bianchi P, Abraham DJ.
Blood. 2001;98:3113.
Description: Study of purified protein of pyruvate kinase and the mutant form (R510Q) found in many patients with pyruvate kinase deficiency to provide a detailed description of the function characterization of human pyruvate kinase.
PubMed citation number: 11698298
Hereditary elliptocytosis, spherocytosis and related disorders: consequences of a deficiency or a mutation of membrane skeletal proteins.
Palek J.
Blood Rev. 1987;1:147-68.
Description: Discussion of the membrane skeletal protein deficiencies involved in hereditary elliptocytosis, spherocytosis, and other similar disorders.
PubMed citation number: 3332099
Treatment
Stable in-vivo expression of glucose-6-phosphate-dehydrogenase (G6PD) and rescue of G6PD deficiency in stem cells by gene transfer.
Rovira A, DeAngioletti M, Camacho-Vanegas O, et al.
Blood 2000;96:4111.
Description: Retroviral vectors with G6PD DNA are transfected into mice with G6PD deficiency.
PubMed citation number: 11110681
Reduced chronic hemolysis during high dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiciency.
Corash L, Spielberg S, Bartsocas C, et al.
N Eng J Med. 1980;303:416-420.
Description: Patients with Mediterranean G6PD deficiency are treated with high-dose vitamin E, resulting in longer red cell survival, higher hemoglobin, and decreased reticulocytosis compared with baseline.
PubMed citation number: 7393270
Review
Clinical manifestations of paroxysmal nocturnal hemoglobinuria: present state and future problems.
Rosse WF, Nishimura J.
Intl J Hematology. 2003;77:113-120.
Description: Review of the pathogenesis, diagnosis, and treatment of PNH.
PubMed citation number:12627845
G6PD deficiency.
Beutler E.
Blood. 1994;84:3613-3636.
Description: Review of G6PD deficiency.
PubMed citation number: 7949118