Teaching Cases - American Society of Hematology


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Teaching Cases

Anemia — Paul K. Schick, MD
Professor of Medicine, Emeritus, Thomas Jefferson Medical College, Philadelphia
Research Professor, Drexel University College of Medicine, Philadelphia
Adjunct Clinical Professor, Lankenau Hospital (LIMR), Wynnewood, PA

I. History	II. Physical Exam	III. Laboratory Data	IV. Differential Diagnosis
V. Pathophysiology	VI. Prognosis/Clinical Course	VII. Teaching Points	VIII. Bibliography

V. PATHOPHYSIOLOGY

There are several compartments of iron in normal individuals:

Hemoglobin in circulating erythrocytes
Iron stores in the reticuloendothelial system
Myoglobin
Serum iron
Tissue stores

Select True or False for each statement about iron compartments.

True False	The loss of 4 pints of blood will deplete iron stores.
True False	Most of the iron in healthy males is sequestered in an iron storage compartment.
True False	Significant depletion of iron stores is usually associated with microcytosis.
True False	Esophageal webbing can be an early sign of iron deficiency.

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