Pathophysiology

Clonal, autonomous proliferation of hematopoietic cells

Cytokine induced increase in bone marrow production, release and demargination of granulocytes, secondary to infection, inflammation or malignancy

Clinical features

Patient often asymptomatic;
Splenomegaly

Signs of infection, inflammation or malignancy

CBC

Granulocytosis with left shift; Thrombocytosis;
Basophilia

Granulocytosis with left shift;
Thrombocytosis (rarely > 1 x 10⁶/mm³)

Cytogenetic studies

Philadelphia chromosome present

Normal

Molecular studies

Chimeric bcr-abl gene present by FISH and PCR analysis

Normal

Treatment

Imatinib mesylate
Allogeneic stem cell transplant

Treat underlying cause