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Teaching Cases

Thrombocytopenia – Terry Gernsheimer, MD, and Michele B. Frank, MD
Dr. Gernsheimer: Puget Sound Blood Center and University of Washington School of Medicine, Seattle, WA; Dr. Frank: Cascade Cancer Center, Kirkland, WA

Copyright of the American Society of Hematology, 2006. ISSN: 1931-6860.


I. HistoryII. Physical ExamIII. Laboratory DataIV. Pathophysiology
V. Differential DiagnosisVI. Prognosis/Clinical CourseVII. Teaching PointsVIII. Bibliography

Petechiae

Pinpoint hemorrhage in the skin producing a red lesion less than 2 mm in size.

This occurs with thrombocytopenia or severe platelet dysfunction and is typically seen in dependent areas such as the lower extremities and under the breasts or, in a bedridden patient, the flanks.

Purpura

Hemorrhage into the skin or subcutaneous tissue producing a purplish discoloration of the skin, commonly known as a bruise.

This can occur with platelet disorders, coagulation abnormalities, or various nonhemostatic disorders. Weakening of the blood vessels or surrounding tissues, such as is seen in vitamin C deficiency, corticosteroid excess, Ehlers-Danlos syndrome and old age, can allow increased extravasation of blood causing purpura.

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