IV. PATHOPHYSIOLOGY

Four Pathophysiologic Mechanisms for Thrombocytopenia

• Decreased Production of Platelets in the Bone Marrow
• Accelerated Destruction of Platelets
• Sequestration of Platelets
• Dilutional Thrombocytopenia

Select each mechanism to learn about the causes.

The history, physical exam and initial laboratory data help to differentiate between the mechanisms of thrombocytopenia. Bone marrow aspirate and biopsy are used to assess the number of megakaryocytes and infer decreased production or destruction, but may not be required for a clinical diagnosis.