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Teaching Cases

Thrombocytopenia – Terry Gernsheimer, MD, and Michele B. Frank, MD
Dr. Gernsheimer: Puget Sound Blood Center and University of Washington School of Medicine, Seattle, WA; Dr. Frank: Cascade Cancer Center, Kirkland, WA

Copyright of the American Society of Hematology, 2006. ISSN: 1931-6860.


I. HistoryII. Physical ExamIII. Laboratory DataIV. Pathophysiology
V. Differential DiagnosisVI. Prognosis/Clinical CourseVII. Teaching PointsVIII. Bibliography

IV. PATHOPHYSIOLOGY

Pathophysiologic Mechanism: Dilutional Thrombocytopenia

Causes:  Massive hemorrhage with blood and fluid resuscitation may result in a fall in the platelet count. Generally loss of at least 1-2 blood volumes occurs before a significant decrease in the platelet count is seen.

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