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Ernest Beutler, MD, was born in Berlin, Germany, in 1928. With the advent of Hitler, he and his family moved to the United States in 1935 and settled in Milwaukee, WI. At age 15, he went to college at the University of Chicago. The intellectual character there fitted his keen mind and he remained at the University of Chicago for medical school and house staff training. He was attracted to hematology by the force of personalities of hematologists at Chicago, particularly Leon Jacobson, and, when he was commissioned as a Second Lieutenant in the Army, he was assigned to work with the Malaria Research Project, where he investigated the abnormality of the red cells that resulted in hemolytic anemia when primaquin was ingested. He noted that these cells had more Heinz bodies than normal when treated with certain chemicals, including iodacetamide. He deduced and then proved that glutathione was more easily oxidized and, from this, that the enzyme glucose-6-phosphate dehydrogenase (G-6-PD) was diminished, opening an entire field of endeavor in hematology and genetics...
Read the full article written by Wendell F. Rosse, MD, in the May/June 2008 issue of The Hematologist.
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