Plasma cell abnormalities are a heterogeneous group of diseases
characterized by production of monoclonal immunoglobulin molecules. The
clinical course of patients with this group of disorders ranges from
indolent to life threatening. It is critical to distinguish patients
for whom long-term observation is appropriate from those who have an
aggressive disease that mandates immediate therapy.
- Identify the general structure of an immunoglobulin
molecule, including the light chains and heavy chains, the constant and
variable regions, the Fab and Fc fragments, and the differences between
the various immunoglobulin classes.
- Name the major criteria used to diagnose multiple myeloma.
- Describe at least five complications that may occur in patients with multiple myeloma.
- Describe the pathophysiology of renal failure in patients with multiple myeloma.
- Describe the pathophysiology, x-ray appearance, complications, and treatment of bone abnormalities in multiple myeloma.
- Describe indications for therapy, treatment, and prognostic indicators for patients with multiple myeloma.
- Define the diagnostic criteria, incidence, and clinical course of patients with monoclonal gammopathy of unknown significance.
- Define amyloid and indicate two proteins that can cause amyloid deposition in tissues.
- Describe the clinical features and prognosis of patients with primary amyloidosis.
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