The Hematologist

May June 2008 Vol 5 Issue 3

May-June 2008, Volume 5, Issue 3

Features

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Diffusion

  • Bedside-to-Laboratory Translational Work Identifies Novel Tumor-Specific AntigenMay 01, 2008 | John C. Byrd, MD

    Chronic lymphocytic leukemia (CLL) is associated with profound suppression of the humoral, innate, and cellular components of the immune system. CLL cells are transformed B lymphocytes but lack classic co-stimulatory molecules typically present on normal B cells.

  • Clinical Penetrance of HFE Hereditary Hemochromatosis, Serum Ferritin Levels, and Screening Implications: Can We Iron This Out?May 01, 2008 | Michael Linenberger, MD

    Since the discovery of the homozygous C282Y mutation of the HFE gene as the major cause of hereditary iron overload in Caucasians of Northern European descent, numerous studies have attempted to define the risk of iron-overload-related disease and a practical rationale for screening.

  • Combination Proteasome Inhibitor TherapyMay 01, 2008 | Kenneth C. Anderson, MD

    The proteasome inhibitor bortezomib, which primarily targets the chymotryptic-like (CT-L) proteolytic activity of the proteasome, is an effective therapy for patients with relapsed refractory multiple myeloma (MM) and is superior to high-dose dexamethasone therapy for relapsed MM.

  • GVHD Has Proteomics Come of Age?May 01, 2008 | Gérard Socié, MD, PhD

    Although graft-versus-host disease (GVHD) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT), its current diagnosis mainly depends on clinical manifestations and invasive biopsies. Early diagnosis of GVHD, preferably based on unbiased laboratory screening tools, may increase the safety of allogeneic HSCT and thus further broaden its application to even larger patient populations.

  • Performance-Enhancing DrugsMay 01, 2008 | Nelson Chao, MD, MBA

    Did Mark McGwire use it or not? We all have our opinions, but we do know that his wife used it. The drug is human growth hormone. Human growth hormone (HGH) is known to improve muscle strength and has been claimed as an anti-aging agent because it can increase lean body mass and bone mineral density, although there are limited data to support this claim.

  • Role of miR223 in MyelopoiesisMay 01, 2008

    New avenues of discovery have opened over the last decade with the discovery of microRNAs. MiRNAs are small RNAs of approximately 22 nucleotide length, which are transcribed from genomic DNA like messenger RNAs (mRNAs) but do not encode proteins. Their main function is that of gene regulation by targeting specific sequences in the 3'-untranslated region of mRNAs.

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Ask the Hematologist

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Profiles

  • Ernest Beutler: Independent Thinker and Astute ObserverMay 01, 2008 | Wendell Rosse, MD

    Ernest Beutler, MD, was born in Berlin, Germany, in 1928. With the advent of Hitler, he and his family moved to the United States in 1935 and settled in Milwaukee, WI. At age 15, he went to college at the University of Chicago. The intellectual character there fitted his keen mind and he remained at the University of Chicago for medical school and house staff training.

  • Ernst R. Jaffé, MD (1925-2008)May 01, 2008 | Helen Ranney, MD

    With the death of Dr. Ernst Jaffé on February 16, 2008, the American Society of Hematology (ASH) lost a visionary founder and a gifted leader of hematology. Present at their creation, he provided wise and devoted leadership to the Albert Einstein College of Medicine, ASH, and Blood.

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Letters to the Editor

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News and Reports

  • International BloodMay 01, 2008 | Cynthia E. Dunbar, MD

    As more biomedical journals around the world institute Web-based electronic submission and publication systems, the dissemination of scientific information worldwide has less respect for national borders. Blood aims to be a venue for the publication of the very best basic and clinical research in hematology from around the world, with no mandate - official or unofficial - to publish more papers emanating from the United States and North America, even though it is owned and published by ASH.

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