- Complement Component C3b and RBCs Provide a Potential Clearance Mechanism for Damaged Plasma ProteinsAugust 12, 2015 | Mark J. Koury, MD
Dr. Koury looks at a study that demonstrates that C3b-mediated erythrocyte clearance of damaged plasma proteins can improve treatment of diseases characterized by tissue accumulation of misfolded or denatured proteins.
- Computed Tomography Provides No Benefit over Routine Screening for Occult CancerAugust 12, 2015 | Tracy I. George, MD
Dr. George evaluates whether there are any advantages to routine screening for occult cancer in using computed tomography (CT).
- Deadly Malaria Parasites Hijack CD55 to Invade Human ErythrocytesAugust 12, 2015 | Theresa Coetzer, PhD
Dr. Coetzer studies how malaria parasites invade human erythrocytes, and the possibility of using hematopoietic stem cell-based forward genetic screening approach to investigate host factors implicated in malaria pathogenesis.
- DUSP4: A New Tumor Suppressor in B-cell Lymphoma With Some Very Druggable TargetsAugust 12, 2015 | Peter Johnson, MD
Dr. Johnson looks at DUSP4 as a new tumor suppressor in B-cell lymphoma.
- Hematopoietic Stem Cells Should Hold Their BreathAugust 12, 2015
Dr. Hoggatt and Hannah Rasmussen discuss new approaches to the use of hematopoietic stem cells considering observer effects that emerge due to our experimental systems for HSCs.
- Shattered Chromosomes: A Cataclysmic Origin of CancerAugust 12, 2015 | Pamela S. Becker, MD, PhD
Dr. Becker discusses an event called chromothripsis, which entails a catastrophic change of genome structure and acquisition of multiple mutations through chromosomal rearrangements, as a cause for cancer.
- Targeted Fetal Hemoglobin Induction Therapy May Need a Blood-Brain BarrierAugust 12, 2015 | Charles T. Quinn, MD, MS
Dr. Quinn talks about safety concerns regarding targeted fetal hemoglobin induction therapy and the role of BCL11A in human neurodevelopment.
- The Evolutionary Trajectory from Diagnosis to Relapse in Pediatric ALLAugust 12, 2015 | Elizabeth Raetz, MD
Dr. Raetz reviews a study that details the trajectory of clonal emergence from diagnosis to relapse in childhood ALL, looking towards earlier detection of genetic lesions that could be a sign of relapse in order to implement alternative therapies before overt disease recurrence.