- Variation in Cancer Risk: Nature, Nurture, and Random ChanceMarch 02, 2015
Dr. George evaluates different causes for carcinogenesis focusing on the stochastic effects associated with the number of stem cell divisions in different organs.
- More Evidence Supporting a Conservative Approach to Red Blood Cell TransfusionFebruary 27, 2015 | David Garcia, MD
Dr. Garcia looks at benefits and risks of different, more conservative hemoglobin thresholds for red blood cell transfusion.
- Factor XI Antisense: A Challenge to Common SenseFebruary 13, 2015 | Adam Cuker, MD, MS
Dr. Cuker evaluates a study that shows targeting FXI is a rather effective antithrombotic therapy while challenging some commonly held misconceptions regarding the treatment.
- H3K27 Demethylases: A New Therapeutic Target in T-ALL?February 13, 2015 | Elizabeth Raetz, MD
Dr. Raetz discusses novel therapeutic approaches for the treatment of T-ALL by looking at H3K27 demethylases in T-ALL initiation and maintenance.
- PD-1 Inhibition and Hodgkin Lymphoma: A Perfect Therapeutic MatchFebruary 13, 2015 | Ann S. LaCasce, MD, MSc
Dr. LaCasce discusses treatment of Hodgkin Lymphoma (HL) with PD-1 Inhibition, and a possibility of combining PD-1 with other novel agents instead of combination chemotherapy.
- The Origin of Therapy-Related AML Lies Deep WithinFebruary 13, 2015 | Pamela S. Becker, MD, PhD
Dr. Becker discusses the origins of therapy-related myelodysplastic syndrome and/or acute myeloid leukemia.
- A Novel Gene Therapy Strategy Provides Hope for HemophiliaFebruary 12, 2015 | Theresa Coetzer, PhD
Dr. Coetzer discusses technological advances that produce a novel approach for gene targeting to treat hemophilia and other inherited enzyme deficiencies.
- Memory Games in the Lymph Node: The Inflammatory Origins of Follicular LymphomaFebruary 12, 2015 | Peter Johnson, MD
Dr. Johnson looks at a series of experiments and describes the origins of Follicular lymphoma (FL) through an observation of molecular events in the lymph nodes.
- Sickle Cell Trait: More Bad News for the Kidneys?February 12, 2015 | Charles T. Quinn, MD, MS
In an attempt to explain racial disparity in the risk of chronic kidney disease, Dr. Quinn discusses the adverse effects of sickle cell trait in the kidneys and an association between sickle cell trait and the occurrence of CKD in African Americans.
- Transitioning to an All Oral Therapy for Multiple Myeloma with the Novel Proteasome Inhibitor IxazomibFebruary 12, 2015
Dr. Yee and Dr. Raje review several trials to explain new courses of treatment for multiple myeloma, specifically an oral, active, well-tolerated PI.