Blasts of a Different Sort
Can you tell what the diagnosis is for a man with a history of recurrent necrotizing pancreatitis and end-stage renal disease on intermittent hemodialysis by looking at his
Combining Daratumumab With Backbone Antimyeloma Agents
Dr. Raje reviews a study that compares daratumumab, lenalidomide, and dexamethasone with lenalidomide and dexamethasone alone for the treatment of patients with multiple my
Insightful critiques and informed commentary of important ongoing clinical trials
Dr. Moss covers a study that compares the PD-1 inhibitor pembrolizumab with brentuximab vedotin in subjects with relapsed or refractory classical HL.
Dr. Garcia discusses a study that tests a new therapeutic approach with antifibrinolytic agents to chemotherapy-associated thrombocytopenia.
Dr. Abdel-Wahab and Dr. Taylor cover a study that measures the safety of combination ABT-199 and hypomethylating agents in older adults with acute myelogenous leukemia (AML), who are treatment-naive and not eligible for standard induction therapy.
Dr. Cuker and Dr. George discuss a study that evaluates the safety, tolerability, and pharmacokinetics of SPK-9001 in subjects with hemophilia B.
Dr. Keel talks about a study that compares risks and benefits of alloHCT in older patients with higher-risk myelodysplastic syndromes.
Dr. Raje and Dr. Yee discuss a study that looks at the use of pembrolizumab in combination with lenalidomide or pomalidomide to treat multiple myeloma as a form of checkpoint inhibition, a new important tool in cancer treatment.
Dr. Stimpson and Dr. DeBaun look at a trial that evaluates research for HCT in severe sickle cell disease using HLA-identical siblings and unrelated donors for HCT compared with standard care due to the absence of a suitable donor.
Dr. Raetz and Dr. Loh cover a new study in pediatric ALL that tests the contribution of ruxolitinib to traditional chemotherapy for newly diagnosed, genetically defined subsets of patients who are known to have poor outcomes with standard therapy.
Dr. Coetzer discusses the N-PhenoGENICS trial and calls for new research to answer questions about secondary effects of chemotherapy in children.
Dr. Quinn discusses the REACH study as part of several studies that look at hydroxyurea for the treatment of children with sickle cell anemia in sub-Saharan Africa.
November-December 2016Volume 13, Issue 6
A new Compendium providing updated clinical information to "Ask the Hematologist" articles published in The Hematologist from 2010 to 2015 is now available.
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by American Society of Hematology