- Is Anybody in Washington Listening?November 01, 2011 | November-December 2011, Volume 8, Issue 6
The fact is nearly all constituent communications are counted and responded to by Members of Congress and their staff. While it is true that individualized communications with some expression of personal sentiment or opinion are most likely to be influential, nearly all legislators do use constituent communications as a gauge of public opinion and integrate it into their decision-making.
- Revised PhRMA Code Goes into Effect: Sunshine or More of the Same?January 01, 2009 | January-February 2009, Volume 6, Issue 1
Recently, we have seen heightened attention by government officials and news media on financial relationships between physicians and manufacturers of pharmaceuticals and medical devices. A few notable cases of physicians and surgeons receiving six-figure "consulting" fees to promote drugs and devices often with little or no public disclosure have heightened interest.
- Another Piece in the Antiphospholipid Antibody Syndrome PuzzleNovember 01, 2007 | November-December 2007, Volume 4, Issue 6
Most patients with the pro-thrombotic condition known as antiphospholipid antibody (APLA) syndrome have circulating autoantibodies reactive with the phospholipid binding plasma protein β
-glycoprotein I (β
-GPI). Although β
-GPI circulates at very high concentrations (3μM) and has been studied for many years, its biologic function remains obscure. In this manuscript, a team from the Netherlands has uncovered a potential role for β
-GPI in regulating primary hemostasis.
- Fetal and Maternal Thrombophilia Genes Cooperate to Influence Pregnancy OutcomesSeptember 01, 2007 | September-October 2007, Volume 4, Issue 5
To study the impact of maternal thrombophilia on pregnancy outcomes, the authors carried out a series of elegant and complicated breeding experiments utilizing multiple mouse strains engineered with genetic defects in the protein C pathway.
- Bcl-2 Proteins Control Platelet Life Span In Vivo: A Potential Target for New Approaches to Treat ThrombocytopeniaJuly 01, 2007 | July-August 2007, Volume 4, Issue 4
Genome-wide mutagenesis (so-called “forward genetics”) has been used widely in non-vertebral model systems (including flies, worms, yeast, and bacteria) to discover pathways involved in numerous cellular processes. Similar approaches have been developed for mouse research, but are not widely used because of the time and costs related to mouse breeding.
- Flossing May Prevent Plaque (of a Different Sort)!May 01, 2007 | May-June 2007, Volume 4, Issue 3
Can aggressive treatment of periodontal disease decrease chronic systemic inflammation and thereby improve vascular function and slow progression of atherosclerosis? To address this intriguing question, investigators from Connecticut and London performed a randomized, blinded clinical study of a group of otherwise healthy subjects with objectively defined severe periodontitis.
- Receptors, Not Clots: Coagulation and Fibrinolytic Enzymes Modulate Stroke Outcome by Targeting Endothelial Cells, Not Cerebral ThrombiMarch 01, 2007 | March-April 2007, Volume 4, Issue 2
brain endothelial cell model of ischemia in which cells were subjected to an environment of oxygen and glucose deprivation, these investigators showed that tissue plasminogen activator (tPA) induced increased expression and activity of MMP9, a matrix metalloproteinase that targets critical components of the blood-brain barrier.
- When Three Months May Not Be Enough - Evidence That a Subgroup of Patients With Venous Thrombosis Identified by Bio-marker Assay Benefits From Long-Term Oral AnticoagulationJanuary 01, 2007 | January-February 2007, Volume 4, Issue 1
In this multicenter prospective study conducted mainly in Italy, investigators studied ~600 patients with a first episode of well documented, unprovoked venous thromboembolism (DVT and/or PE). After completing at least three months of oral anticoagulation (OAC) therapy with vitamin K antagonists, all subjects stopped therapy and ~30d later underwent qualitative testing for d-dimer and a limited thrombophilia panel.
- Coordination of the Systemic Inflammatory Response by Brain-Spleen CommunicationSeptember 01, 2006 | September-October 2006, Volume 3, Issue 5
A research team led by Kevin Tracy at North Shore-LIJ Health System in New York has recently discovered and characterized an anti-inflammatory pathway mediated by acetylcholine (Ach) interactions with specific α7 nicotinic receptors on macrophages. They termed this the “cholinergic anti-inflammatory pathway” and showed that the central nervous system participates by releasing Ach from the efferent vagus nerve.
- Venous Thrombosis Makes News in WashingtonSeptember 01, 2006 | September-October 2006, Volume 3, Issue 5
By some estimates, nearly 900,000 Americans each year suffer a serious venous thromboembolic (VTE) event - deep vein thrombosis (DVT) and/or pulmonary embolism (PE). Despite significant knowledge of important risk factors, such as surgery, trauma, hospitalization for medical illness, cancer, and advanced age, annual death rates from VTE exceed those for myocardial infarction and stroke combined.